The MTHFR 677T Allele May Influence the Severity and Biochemical Risk Factors of Alzheimer’s Disease in an Egyptian Population
المؤلفون المشاركون
Elhawary, Nasser Attia
Hewedi, Doaa
Arab, Arwa
Teama, Salwa
Shaibah, Hassan
Tayeb, Mohammed Taher
Bogari, Neda
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
We evaluated whether the methylenetetrahydrofolate reductase (MTHFR) 677C>T marker influences the risk and severity of Alzheimer's disease (AD) and whether AD is associated with homocysteine, vitamin B12, and cholesterol levels in Egypt.
Methods.
Forty-three Alzheimer's cases and 32 non-AD controls were genotyped for the 677C>T polymorphism.
Clinical characteristics and levels of homocysteine, vitamin B12, and cholesterol were assessed.
Results.
No significant differences in the frequencies of the MTHFR alleles or genotypes between AD cases and controls (P=0.14) were identified.
The 677T mutant allele was significantly overrepresented in AD cases compared to controls (OR=2.22; P=0.03).
The 677T/T frequency was three times higher in AD patients than in controls, which could increase plasma homocysteine levels.
Severe cases of AD were the most frequent in patients with the T/T genotype (11.6%).
The effect of the MTHFR polymorphism on the risk of AD may be independent of homocysteine, vitamin B12, or even cholesterol levels.
Conclusions.
The MTHFR 677C>T polymorphism—especially the presence of one copy of the T allele—appears to confer a potential risk for the development of AD.
The T/T genotype may contribute to hypercysteinemia as a sensitive marker.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Elhawary, Nasser Attia& Hewedi, Doaa& Arab, Arwa& Teama, Salwa& Shaibah, Hassan& Tayeb, Mohammed Taher…[et al.]. 2013. The MTHFR 677T Allele May Influence the Severity and Biochemical Risk Factors of Alzheimer’s Disease in an Egyptian Population. Disease Markers،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005837
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Elhawary, Nasser Attia…[et al.]. The MTHFR 677T Allele May Influence the Severity and Biochemical Risk Factors of Alzheimer’s Disease in an Egyptian Population. Disease Markers No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1005837
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Elhawary, Nasser Attia& Hewedi, Doaa& Arab, Arwa& Teama, Salwa& Shaibah, Hassan& Tayeb, Mohammed Taher…[et al.]. The MTHFR 677T Allele May Influence the Severity and Biochemical Risk Factors of Alzheimer’s Disease in an Egyptian Population. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005837
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005837
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر