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The MTHFR 677T Allele May Influence the Severity and Biochemical Risk Factors of Alzheimer’s Disease in an Egyptian Population
Joint Authors
Elhawary, Nasser Attia
Hewedi, Doaa
Arab, Arwa
Teama, Salwa
Shaibah, Hassan
Tayeb, Mohammed Taher
Bogari, Neda
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We evaluated whether the methylenetetrahydrofolate reductase (MTHFR) 677C>T marker influences the risk and severity of Alzheimer's disease (AD) and whether AD is associated with homocysteine, vitamin B12, and cholesterol levels in Egypt.
Methods.
Forty-three Alzheimer's cases and 32 non-AD controls were genotyped for the 677C>T polymorphism.
Clinical characteristics and levels of homocysteine, vitamin B12, and cholesterol were assessed.
Results.
No significant differences in the frequencies of the MTHFR alleles or genotypes between AD cases and controls (P=0.14) were identified.
The 677T mutant allele was significantly overrepresented in AD cases compared to controls (OR=2.22; P=0.03).
The 677T/T frequency was three times higher in AD patients than in controls, which could increase plasma homocysteine levels.
Severe cases of AD were the most frequent in patients with the T/T genotype (11.6%).
The effect of the MTHFR polymorphism on the risk of AD may be independent of homocysteine, vitamin B12, or even cholesterol levels.
Conclusions.
The MTHFR 677C>T polymorphism—especially the presence of one copy of the T allele—appears to confer a potential risk for the development of AD.
The T/T genotype may contribute to hypercysteinemia as a sensitive marker.
American Psychological Association (APA)
Elhawary, Nasser Attia& Hewedi, Doaa& Arab, Arwa& Teama, Salwa& Shaibah, Hassan& Tayeb, Mohammed Taher…[et al.]. 2013. The MTHFR 677T Allele May Influence the Severity and Biochemical Risk Factors of Alzheimer’s Disease in an Egyptian Population. Disease Markers،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005837
Modern Language Association (MLA)
Elhawary, Nasser Attia…[et al.]. The MTHFR 677T Allele May Influence the Severity and Biochemical Risk Factors of Alzheimer’s Disease in an Egyptian Population. Disease Markers No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1005837
American Medical Association (AMA)
Elhawary, Nasser Attia& Hewedi, Doaa& Arab, Arwa& Teama, Salwa& Shaibah, Hassan& Tayeb, Mohammed Taher…[et al.]. The MTHFR 677T Allele May Influence the Severity and Biochemical Risk Factors of Alzheimer’s Disease in an Egyptian Population. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005837
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005837