Coding and Noncoding Gene Expression Biomarkers in Mood Disorders and Schizophrenia
المؤلفون المشاركون
Mamdani, Firoza
Martin, Maureen V.
Lencz, Todd
Rollins, Brandi
Robinson, Delbert G.
Moon, Emily A.
Malhotra, Anil K.
Vawter, Marquis P.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Mood disorders and schizophrenia are common and complex disorders with consistent evidence of genetic and environmental influences on predisposition.
It is generally believed that the consequences of disease, gene expression, and allelic heterogeneity may be partly the explanation for the variability observed in treatment response.
Correspondingly, while effective treatments are available for some patients, approximately half of the patients fail to respond to current neuropsychiatric treatments.
A number of peripheral gene expression studies have been conducted to understand these brain-based disorders and mechanisms of treatment response with the aim of identifying suitable biomarkers and perhaps subgroups of patients based upon molecular fingerprint.
In this review, we summarize the results from blood-derived gene expression studies implemented with the aim of discovering biomarkers for treatment response and classification of disorders.
We include data from a biomarker study conducted in first-episode subjects with schizophrenia, where the results provide insight into possible individual biological differences that predict antipsychotic response.
It is concluded that, while peripheral studies of expression are generating valuable results in pathways involving immune regulation and response, larger studies are required which hopefully will lead to robust biomarkers for treatment response and perhaps underlying variations relevant to these complex disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mamdani, Firoza& Martin, Maureen V.& Lencz, Todd& Rollins, Brandi& Robinson, Delbert G.& Moon, Emily A.…[et al.]. 2013. Coding and Noncoding Gene Expression Biomarkers in Mood Disorders and Schizophrenia. Disease Markers،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1005866
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mamdani, Firoza…[et al.]. Coding and Noncoding Gene Expression Biomarkers in Mood Disorders and Schizophrenia. Disease Markers No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1005866
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mamdani, Firoza& Martin, Maureen V.& Lencz, Todd& Rollins, Brandi& Robinson, Delbert G.& Moon, Emily A.…[et al.]. Coding and Noncoding Gene Expression Biomarkers in Mood Disorders and Schizophrenia. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1005866
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005866
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر