Coding and Noncoding Gene Expression Biomarkers in Mood Disorders and Schizophrenia
Joint Authors
Mamdani, Firoza
Martin, Maureen V.
Lencz, Todd
Rollins, Brandi
Robinson, Delbert G.
Moon, Emily A.
Malhotra, Anil K.
Vawter, Marquis P.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Mood disorders and schizophrenia are common and complex disorders with consistent evidence of genetic and environmental influences on predisposition.
It is generally believed that the consequences of disease, gene expression, and allelic heterogeneity may be partly the explanation for the variability observed in treatment response.
Correspondingly, while effective treatments are available for some patients, approximately half of the patients fail to respond to current neuropsychiatric treatments.
A number of peripheral gene expression studies have been conducted to understand these brain-based disorders and mechanisms of treatment response with the aim of identifying suitable biomarkers and perhaps subgroups of patients based upon molecular fingerprint.
In this review, we summarize the results from blood-derived gene expression studies implemented with the aim of discovering biomarkers for treatment response and classification of disorders.
We include data from a biomarker study conducted in first-episode subjects with schizophrenia, where the results provide insight into possible individual biological differences that predict antipsychotic response.
It is concluded that, while peripheral studies of expression are generating valuable results in pathways involving immune regulation and response, larger studies are required which hopefully will lead to robust biomarkers for treatment response and perhaps underlying variations relevant to these complex disorders.
American Psychological Association (APA)
Mamdani, Firoza& Martin, Maureen V.& Lencz, Todd& Rollins, Brandi& Robinson, Delbert G.& Moon, Emily A.…[et al.]. 2013. Coding and Noncoding Gene Expression Biomarkers in Mood Disorders and Schizophrenia. Disease Markers،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1005866
Modern Language Association (MLA)
Mamdani, Firoza…[et al.]. Coding and Noncoding Gene Expression Biomarkers in Mood Disorders and Schizophrenia. Disease Markers No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1005866
American Medical Association (AMA)
Mamdani, Firoza& Martin, Maureen V.& Lencz, Todd& Rollins, Brandi& Robinson, Delbert G.& Moon, Emily A.…[et al.]. Coding and Noncoding Gene Expression Biomarkers in Mood Disorders and Schizophrenia. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1005866
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005866