Serum Anti-CCNY Autoantibody Is an Independent Prognosis Indicator for Postoperative Patients with Early-Stage Nonsmall-Cell Lung Carcinoma

المؤلفون المشاركون

Ma, Li
Yue, Wentao
Teng, Yu
Zhang, Lina
Gu, Meng
Wang, Yue

المصدر

Disease Markers

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-09-18

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الأمراض

الملخص EN

Cyclin Y (CCNY) is a novel cyclin and almost nothing is known about its role in human cancers.

To investigate the clinical significance of serum anti-CCNY autoantibodies in nonsmall-cell lung carcinoma (NSCLC), the serum levels of CCNY protein in 264 patients with NSCLC, 103 patients with tuberculosis, and 89 healthy controls were analyzed by immunohistochemistry.

The result shows that, compared with normal lung tissues, the NSCLC tissues contained higher levels of CCNY protein.

The levels of anti-CCNY autoantibodies were higher in the sera of the patients with NSCLC than in the sera of the healthy controls (P<0.001) or the patients with tuberculosis (P=0.027).

Moreover, in a Cox regression analysis, anti-CCNY autoantibody was an independent factor that predicted poor prognosis for postoperative patients with early-stage NSCLC (P=0.026) as well as for those with distant metastasis (P=0.012).

Our data indicated that Anti-CCNY autoantibody may be useful as a latent tumor marker to facilitate diagnosis and may represent a novel prognostic indicator for patients with early stage NSCLC.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Ma, Li& Yue, Wentao& Teng, Yu& Zhang, Lina& Gu, Meng& Wang, Yue. 2013. Serum Anti-CCNY Autoantibody Is an Independent Prognosis Indicator for Postoperative Patients with Early-Stage Nonsmall-Cell Lung Carcinoma. Disease Markers،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1005895

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Ma, Li…[et al.]. Serum Anti-CCNY Autoantibody Is an Independent Prognosis Indicator for Postoperative Patients with Early-Stage Nonsmall-Cell Lung Carcinoma. Disease Markers No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1005895

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Ma, Li& Yue, Wentao& Teng, Yu& Zhang, Lina& Gu, Meng& Wang, Yue. Serum Anti-CCNY Autoantibody Is an Independent Prognosis Indicator for Postoperative Patients with Early-Stage Nonsmall-Cell Lung Carcinoma. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1005895

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1005895