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Serum Anti-CCNY Autoantibody Is an Independent Prognosis Indicator for Postoperative Patients with Early-Stage Nonsmall-Cell Lung Carcinoma
Joint Authors
Ma, Li
Yue, Wentao
Teng, Yu
Zhang, Lina
Gu, Meng
Wang, Yue
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cyclin Y (CCNY) is a novel cyclin and almost nothing is known about its role in human cancers.
To investigate the clinical significance of serum anti-CCNY autoantibodies in nonsmall-cell lung carcinoma (NSCLC), the serum levels of CCNY protein in 264 patients with NSCLC, 103 patients with tuberculosis, and 89 healthy controls were analyzed by immunohistochemistry.
The result shows that, compared with normal lung tissues, the NSCLC tissues contained higher levels of CCNY protein.
The levels of anti-CCNY autoantibodies were higher in the sera of the patients with NSCLC than in the sera of the healthy controls (P<0.001) or the patients with tuberculosis (P=0.027).
Moreover, in a Cox regression analysis, anti-CCNY autoantibody was an independent factor that predicted poor prognosis for postoperative patients with early-stage NSCLC (P=0.026) as well as for those with distant metastasis (P=0.012).
Our data indicated that Anti-CCNY autoantibody may be useful as a latent tumor marker to facilitate diagnosis and may represent a novel prognostic indicator for patients with early stage NSCLC.
American Psychological Association (APA)
Ma, Li& Yue, Wentao& Teng, Yu& Zhang, Lina& Gu, Meng& Wang, Yue. 2013. Serum Anti-CCNY Autoantibody Is an Independent Prognosis Indicator for Postoperative Patients with Early-Stage Nonsmall-Cell Lung Carcinoma. Disease Markers،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1005895
Modern Language Association (MLA)
Ma, Li…[et al.]. Serum Anti-CCNY Autoantibody Is an Independent Prognosis Indicator for Postoperative Patients with Early-Stage Nonsmall-Cell Lung Carcinoma. Disease Markers No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1005895
American Medical Association (AMA)
Ma, Li& Yue, Wentao& Teng, Yu& Zhang, Lina& Gu, Meng& Wang, Yue. Serum Anti-CCNY Autoantibody Is an Independent Prognosis Indicator for Postoperative Patients with Early-Stage Nonsmall-Cell Lung Carcinoma. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1005895
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005895