![](/images/graphics-bg.png)
FAS and FASL Gene Polymorphisms Are Not Associated with Hepatitis B Virus Infection Based on a Case-Control Study in a Brazilian Population
المؤلفون المشاركون
Ishak, Ricardo
Santana, Bárbara B.
Viégas, Maria Luana C.
Conde, Simone R. S. S.
Ishak, Marluísa O. G.
Rosário Vallinoto, Antonio Carlos
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-17
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
This study investigated the association of the single nucleotide polymorphisms (SNPs) in the FAS and FASL genes with the outcome of hepatitis B virus (HBV) infection.
Methods.
Blood samples were collected from 116 HBV-infected patients at the Hospital of the Santa Casa de Misericordia Foundation (Belém, PA, Brazil).
Seronegative individuals were used as controls.
DNA samples were extracted from the leukocytes and assayed using the polymerase chain reaction (PCR) followed by RFLP analysis with restriction endonucleases.
Results.
The frequencies of the mutant genotypes for -670FAS (GG), Ivs2nt-124FASL (GG), Ivs3nt-169FASL (ΔT/ΔT), and -844FASL (TT) were higher in the HBV patients, and the FAS-1377AA genotype was more frequent in the control group; however, the differences between the allele and genotype frequencies were not statistically significant.
When the HBV patient population was divided into two groups (inactive carriers and active chronic hepatitis patients), the mutant genotypes were found to be more prevalent in the active chronic hepatitis group with respect to the FAS gene polymorphisms; however, this difference was not statistically significant.
Conclusions.
The results suggest that the polymorphisms in FAS and FASL genes are not associated with HBV infection or even with the natural history of the infection in the Brazilian Amazon region.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Santana, Bárbara B.& Viégas, Maria Luana C.& Conde, Simone R. S. S.& Ishak, Marluísa O. G.& Ishak, Ricardo& Rosário Vallinoto, Antonio Carlos. 2013. FAS and FASL Gene Polymorphisms Are Not Associated with Hepatitis B Virus Infection Based on a Case-Control Study in a Brazilian Population. Disease Markers،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005898
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Santana, Bárbara B.…[et al.]. FAS and FASL Gene Polymorphisms Are Not Associated with Hepatitis B Virus Infection Based on a Case-Control Study in a Brazilian Population. Disease Markers No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1005898
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Santana, Bárbara B.& Viégas, Maria Luana C.& Conde, Simone R. S. S.& Ishak, Marluísa O. G.& Ishak, Ricardo& Rosário Vallinoto, Antonio Carlos. FAS and FASL Gene Polymorphisms Are Not Associated with Hepatitis B Virus Infection Based on a Case-Control Study in a Brazilian Population. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005898
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005898
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)