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FAS and FASL Gene Polymorphisms Are Not Associated with Hepatitis B Virus Infection Based on a Case-Control Study in a Brazilian Population
Joint Authors
Ishak, Ricardo
Santana, Bárbara B.
Viégas, Maria Luana C.
Conde, Simone R. S. S.
Ishak, Marluísa O. G.
Rosário Vallinoto, Antonio Carlos
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This study investigated the association of the single nucleotide polymorphisms (SNPs) in the FAS and FASL genes with the outcome of hepatitis B virus (HBV) infection.
Methods.
Blood samples were collected from 116 HBV-infected patients at the Hospital of the Santa Casa de Misericordia Foundation (Belém, PA, Brazil).
Seronegative individuals were used as controls.
DNA samples were extracted from the leukocytes and assayed using the polymerase chain reaction (PCR) followed by RFLP analysis with restriction endonucleases.
Results.
The frequencies of the mutant genotypes for -670FAS (GG), Ivs2nt-124FASL (GG), Ivs3nt-169FASL (ΔT/ΔT), and -844FASL (TT) were higher in the HBV patients, and the FAS-1377AA genotype was more frequent in the control group; however, the differences between the allele and genotype frequencies were not statistically significant.
When the HBV patient population was divided into two groups (inactive carriers and active chronic hepatitis patients), the mutant genotypes were found to be more prevalent in the active chronic hepatitis group with respect to the FAS gene polymorphisms; however, this difference was not statistically significant.
Conclusions.
The results suggest that the polymorphisms in FAS and FASL genes are not associated with HBV infection or even with the natural history of the infection in the Brazilian Amazon region.
American Psychological Association (APA)
Santana, Bárbara B.& Viégas, Maria Luana C.& Conde, Simone R. S. S.& Ishak, Marluísa O. G.& Ishak, Ricardo& Rosário Vallinoto, Antonio Carlos. 2013. FAS and FASL Gene Polymorphisms Are Not Associated with Hepatitis B Virus Infection Based on a Case-Control Study in a Brazilian Population. Disease Markers،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005898
Modern Language Association (MLA)
Santana, Bárbara B.…[et al.]. FAS and FASL Gene Polymorphisms Are Not Associated with Hepatitis B Virus Infection Based on a Case-Control Study in a Brazilian Population. Disease Markers No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1005898
American Medical Association (AMA)
Santana, Bárbara B.& Viégas, Maria Luana C.& Conde, Simone R. S. S.& Ishak, Marluísa O. G.& Ishak, Ricardo& Rosário Vallinoto, Antonio Carlos. FAS and FASL Gene Polymorphisms Are Not Associated with Hepatitis B Virus Infection Based on a Case-Control Study in a Brazilian Population. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005898
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005898