Role of Th17 Cells in Skin Inflammation of Allergic Contact Dermatits
المؤلف
المصدر
Journal of Immunology Research
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Extending the classical concept considering an imbalance exclusively of T helper(h) 1 and Th2 cells on the bottom of many inflammatory diseases, Th17 cells were recently described.
Today, there is sufficient experimental evidence to classify psoriasis and allergic contact dermatitis (ACD) amongst other inflammatory skin disorders as IL-17 associated diseases.
In several human studies, T-cell-clones could be isolated from eczema biopsies, and high IL-17 levels were observed after challenge with allergen.
In the last years, the phenotype of these IL-17 releasing T cells was in the focus of discussion.
It has been suggested that Th17 could be identified by expression of retinoic acid receptor-related orphan receptor (ROR)C (humans) or RORγt (mice) and IL-17, accompanied by the absence of IFN-γ and IL-22.
In cells from skin biopsies, contact allergens elevate IL-17A, IL-23, and RORC within the subset of Th cells.
The indications for a participation of Th17 in the development of ACD are supported by data from IL-17 deficient mice with reduced contact hypersensitivity (CHS) reactions that could be restored after transplantation of wild type CD4+ T cells.
In addition to Th17 cells, subpopulations of CD8+ T cells and regulatory T cells are further sources of IL-17 that play important roles in ACD as well.
Finally, the results from Th17 cell research allow today identification of different skin diseases by a specific profile of signature cytokines from Th cells that can be used as a future diagnostic tool.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Peiser, Matthias. 2013. Role of Th17 Cells in Skin Inflammation of Allergic Contact Dermatits. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1006514
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Peiser, Matthias. Role of Th17 Cells in Skin Inflammation of Allergic Contact Dermatits. Journal of Immunology Research No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1006514
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Peiser, Matthias. Role of Th17 Cells in Skin Inflammation of Allergic Contact Dermatits. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1006514
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1006514
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر