Role of Th17 Cells in Skin Inflammation of Allergic Contact Dermatits
Author
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Extending the classical concept considering an imbalance exclusively of T helper(h) 1 and Th2 cells on the bottom of many inflammatory diseases, Th17 cells were recently described.
Today, there is sufficient experimental evidence to classify psoriasis and allergic contact dermatitis (ACD) amongst other inflammatory skin disorders as IL-17 associated diseases.
In several human studies, T-cell-clones could be isolated from eczema biopsies, and high IL-17 levels were observed after challenge with allergen.
In the last years, the phenotype of these IL-17 releasing T cells was in the focus of discussion.
It has been suggested that Th17 could be identified by expression of retinoic acid receptor-related orphan receptor (ROR)C (humans) or RORγt (mice) and IL-17, accompanied by the absence of IFN-γ and IL-22.
In cells from skin biopsies, contact allergens elevate IL-17A, IL-23, and RORC within the subset of Th cells.
The indications for a participation of Th17 in the development of ACD are supported by data from IL-17 deficient mice with reduced contact hypersensitivity (CHS) reactions that could be restored after transplantation of wild type CD4+ T cells.
In addition to Th17 cells, subpopulations of CD8+ T cells and regulatory T cells are further sources of IL-17 that play important roles in ACD as well.
Finally, the results from Th17 cell research allow today identification of different skin diseases by a specific profile of signature cytokines from Th cells that can be used as a future diagnostic tool.
American Psychological Association (APA)
Peiser, Matthias. 2013. Role of Th17 Cells in Skin Inflammation of Allergic Contact Dermatits. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1006514
Modern Language Association (MLA)
Peiser, Matthias. Role of Th17 Cells in Skin Inflammation of Allergic Contact Dermatits. Journal of Immunology Research No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1006514
American Medical Association (AMA)
Peiser, Matthias. Role of Th17 Cells in Skin Inflammation of Allergic Contact Dermatits. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1006514
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006514