Combination of Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Genetic Background Influences the Onset Age of Hepatocellular Carcinoma in Male Patients with Hepatitis B Virus Infection
المؤلفون المشاركون
Xie, Wei
Shi, Qian
Jin, Hui
Sun, Hang
Zhang, Jianqiong
Jiang, Wei
He, Youji
Miao, Fengqin
Qiu, Jie
Pan, Ning
Xu, Jinhuan
المصدر
Journal of Immunology Research
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
To investigate whether killer cell immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA) genetic background could influence the onset age of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) infection, one hundred and seventy-one males with HBV-related HCC were enrolled.
The presence of 12 loci of KIR was detected individually.
HLA-A, -B, and -C loci were genotyped with high resolution by a routine sequence-based typing method.
The effect of each KIR locus, HLA ligand, and HLA-KIR combination was examined individually by Kaplan-Meier (KM) analysis.
Multivariate Cox hazard regression model was also applied.
We identified C1C1-KIR2DS2/2DL2 as an independent risk factor for earlier onset age of HCC (median onset age was 44 for C1C1-KIR2DS2/2DL2 positive patients compared to 50 for negative patients, P=0.04 for KM analysis; HR = 1.70, P=0.004 for multivariate Cox model).
We conclude that KIR and HLA genetic background can influence the onset age of HCC in male patients with HBV infection.
This study may be useful to improve the current HCC surveillance program in HBV-infected patients.
Our findings also suggest an important role of natural killer cells (or other KIR-expressing cells) in the progress of HBV-related HCC development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pan, Ning& Qiu, Jie& Sun, Hang& Miao, Fengqin& Shi, Qian& Xu, Jinhuan…[et al.]. 2013. Combination of Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Genetic Background Influences the Onset Age of Hepatocellular Carcinoma in Male Patients with Hepatitis B Virus Infection. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1006985
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pan, Ning…[et al.]. Combination of Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Genetic Background Influences the Onset Age of Hepatocellular Carcinoma in Male Patients with Hepatitis B Virus Infection. Journal of Immunology Research No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1006985
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pan, Ning& Qiu, Jie& Sun, Hang& Miao, Fengqin& Shi, Qian& Xu, Jinhuan…[et al.]. Combination of Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Genetic Background Influences the Onset Age of Hepatocellular Carcinoma in Male Patients with Hepatitis B Virus Infection. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1006985
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1006985
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر