Combination of Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Genetic Background Influences the Onset Age of Hepatocellular Carcinoma in Male Patients with Hepatitis B Virus Infection
Joint Authors
Xie, Wei
Shi, Qian
Jin, Hui
Sun, Hang
Zhang, Jianqiong
Jiang, Wei
He, Youji
Miao, Fengqin
Qiu, Jie
Pan, Ning
Xu, Jinhuan
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
To investigate whether killer cell immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA) genetic background could influence the onset age of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) infection, one hundred and seventy-one males with HBV-related HCC were enrolled.
The presence of 12 loci of KIR was detected individually.
HLA-A, -B, and -C loci were genotyped with high resolution by a routine sequence-based typing method.
The effect of each KIR locus, HLA ligand, and HLA-KIR combination was examined individually by Kaplan-Meier (KM) analysis.
Multivariate Cox hazard regression model was also applied.
We identified C1C1-KIR2DS2/2DL2 as an independent risk factor for earlier onset age of HCC (median onset age was 44 for C1C1-KIR2DS2/2DL2 positive patients compared to 50 for negative patients, P=0.04 for KM analysis; HR = 1.70, P=0.004 for multivariate Cox model).
We conclude that KIR and HLA genetic background can influence the onset age of HCC in male patients with HBV infection.
This study may be useful to improve the current HCC surveillance program in HBV-infected patients.
Our findings also suggest an important role of natural killer cells (or other KIR-expressing cells) in the progress of HBV-related HCC development.
American Psychological Association (APA)
Pan, Ning& Qiu, Jie& Sun, Hang& Miao, Fengqin& Shi, Qian& Xu, Jinhuan…[et al.]. 2013. Combination of Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Genetic Background Influences the Onset Age of Hepatocellular Carcinoma in Male Patients with Hepatitis B Virus Infection. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1006985
Modern Language Association (MLA)
Pan, Ning…[et al.]. Combination of Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Genetic Background Influences the Onset Age of Hepatocellular Carcinoma in Male Patients with Hepatitis B Virus Infection. Journal of Immunology Research No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1006985
American Medical Association (AMA)
Pan, Ning& Qiu, Jie& Sun, Hang& Miao, Fengqin& Shi, Qian& Xu, Jinhuan…[et al.]. Combination of Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Genetic Background Influences the Onset Age of Hepatocellular Carcinoma in Male Patients with Hepatitis B Virus Infection. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1006985
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006985