Effects of Edaravone, a Free Radical Scavenger, on Photochemically Induced Cerebral Infarction in a Rat Hemiplegic Model
المؤلفون المشاركون
Ikeda, Satoshi
Harada, Katsuhiro
Ohwatashi, Akihiko
Kamikawa, Yurie
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-17
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Edaravone is a free radical scavenger that protects the adjacent cortex during cerebral infarction.
We created a hemiparetic model of cerebral thrombosis from a photochemically induced infarction with the photosensitive dye, rose bengal, in rats.
We examined the effects of edaravone on recovery in the model.
A total of 36 adult Wistar rats were used.
The right sensorimotor area was irradiated with green light with a wavelength of 533 nm (10 mm diameter), and the rose bengal was injected intravenously to create an infarction.
The edaravone group was injected intraperitoneally with edaravone (3 mg/kg), and the control group was injected with saline.
The recovery process of the hemiplegia was evaluated with the 7-step scale of Fenny.
The infarcted areas were measured after fixation.
The recovery of the paralysis in the edaravone-treated group was significantly earlier than that in the untreated group.
Seven days later, both groups were mostly recovered and had scores of 7, and the infarction region was significantly smaller in the edaravone-treated group.
Edaravone reduced the infarction area and promoted the functional recovery of hemiparesis from cerebral thrombosis in a rat model.
These findings suggest that edaravone treatment would be effective in clinical patients recovering from cerebral infarction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ikeda, Satoshi& Harada, Katsuhiro& Ohwatashi, Akihiko& Kamikawa, Yurie. 2013. Effects of Edaravone, a Free Radical Scavenger, on Photochemically Induced Cerebral Infarction in a Rat Hemiplegic Model. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1011607
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ikeda, Satoshi…[et al.]. Effects of Edaravone, a Free Radical Scavenger, on Photochemically Induced Cerebral Infarction in a Rat Hemiplegic Model. The Scientific World Journal No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1011607
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ikeda, Satoshi& Harada, Katsuhiro& Ohwatashi, Akihiko& Kamikawa, Yurie. Effects of Edaravone, a Free Radical Scavenger, on Photochemically Induced Cerebral Infarction in a Rat Hemiplegic Model. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1011607
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1011607
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر