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Effects of Edaravone, a Free Radical Scavenger, on Photochemically Induced Cerebral Infarction in a Rat Hemiplegic Model
Joint Authors
Ikeda, Satoshi
Harada, Katsuhiro
Ohwatashi, Akihiko
Kamikawa, Yurie
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Edaravone is a free radical scavenger that protects the adjacent cortex during cerebral infarction.
We created a hemiparetic model of cerebral thrombosis from a photochemically induced infarction with the photosensitive dye, rose bengal, in rats.
We examined the effects of edaravone on recovery in the model.
A total of 36 adult Wistar rats were used.
The right sensorimotor area was irradiated with green light with a wavelength of 533 nm (10 mm diameter), and the rose bengal was injected intravenously to create an infarction.
The edaravone group was injected intraperitoneally with edaravone (3 mg/kg), and the control group was injected with saline.
The recovery process of the hemiplegia was evaluated with the 7-step scale of Fenny.
The infarcted areas were measured after fixation.
The recovery of the paralysis in the edaravone-treated group was significantly earlier than that in the untreated group.
Seven days later, both groups were mostly recovered and had scores of 7, and the infarction region was significantly smaller in the edaravone-treated group.
Edaravone reduced the infarction area and promoted the functional recovery of hemiparesis from cerebral thrombosis in a rat model.
These findings suggest that edaravone treatment would be effective in clinical patients recovering from cerebral infarction.
American Psychological Association (APA)
Ikeda, Satoshi& Harada, Katsuhiro& Ohwatashi, Akihiko& Kamikawa, Yurie. 2013. Effects of Edaravone, a Free Radical Scavenger, on Photochemically Induced Cerebral Infarction in a Rat Hemiplegic Model. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1011607
Modern Language Association (MLA)
Ikeda, Satoshi…[et al.]. Effects of Edaravone, a Free Radical Scavenger, on Photochemically Induced Cerebral Infarction in a Rat Hemiplegic Model. The Scientific World Journal No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1011607
American Medical Association (AMA)
Ikeda, Satoshi& Harada, Katsuhiro& Ohwatashi, Akihiko& Kamikawa, Yurie. Effects of Edaravone, a Free Radical Scavenger, on Photochemically Induced Cerebral Infarction in a Rat Hemiplegic Model. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1011607
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1011607