Molecular Docking Study of Conformational Polymorph: Building Block of Crystal Chemistry

الملخص EN

Two conformational polymorphs of novel 2-[2-(3-cyano-4,6-dimethyl-2-oxo-2H-pyridin-1-yl)-ethoxy]-4,6-dimethyl nicotinonitrile have been developed.

The crystal structure of both polymorphs (1a and 1b) seems to be stabilized by weak interactions.

A difference was observed in the packing of both polymorphs.

Polymorph 1b has a better binding affinity with the cyclooxygenase (COX-2) receptor than the standard (Nimesulide).