Possible Protective Effect of Sertraline against Cisplatin-Induced Ototoxicity: An Experimental Study
المؤلفون المشاركون
Ozturk, Murat
Ucar, Selcuk
Sarı, Fatih
Erdogan, Selvet
Topdag, Murat
Iseri, Mete
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-01
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Cisplatin is a widely used chemotherapeutic agent, but its ototoxicity side effect can occur in the majority of patients.
Lots of agents were tried to prevent this, but there is not a routine treatment modality yet.
The aim of this study was to evaluate the otoprotective effect of sertraline, which is an antidepressant with neuroprotective effects, against cisplatin, in rats.
Design.
Experimental animal study.
Material and Methods.
Forty-eight rats were randomly separated in two groups as groups I and II.
Group I was identified as the control group and only a single dose of intraperitoneal cisplatin was administered.
In group II, in addition to cisplatin, sertraline was administered to the rats through an oral cannula for ten-day period.
Distortion product otoacoustic emission measurements were performed at the first day and the 10th day.
Results.
When the ototoxicity rates after cisplatin in group I and group II in distortion product otoacoustic emission measurements were compared, it was statistically significantly lower in group II in frequencies of 5652, 6165, 6726, 7336, and 7996 Hz (P<0.05).
Conclusion.
Sertraline seems to have a protective effect on cisplatin ototoxicity and could be used to prevent the ototoxicity and also to treat the depression that occurred in cancer patients together.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ozturk, Murat& Ucar, Selcuk& Sarı, Fatih& Erdogan, Selvet& Topdag, Murat& Iseri, Mete. 2013. Possible Protective Effect of Sertraline against Cisplatin-Induced Ototoxicity: An Experimental Study. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1012463
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ozturk, Murat…[et al.]. Possible Protective Effect of Sertraline against Cisplatin-Induced Ototoxicity: An Experimental Study. The Scientific World Journal No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1012463
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ozturk, Murat& Ucar, Selcuk& Sarı, Fatih& Erdogan, Selvet& Topdag, Murat& Iseri, Mete. Possible Protective Effect of Sertraline against Cisplatin-Induced Ototoxicity: An Experimental Study. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1012463
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1012463
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر