Possible Protective Effect of Sertraline against Cisplatin-Induced Ototoxicity: An Experimental Study
Joint Authors
Ozturk, Murat
Ucar, Selcuk
Sarı, Fatih
Erdogan, Selvet
Topdag, Murat
Iseri, Mete
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Cisplatin is a widely used chemotherapeutic agent, but its ototoxicity side effect can occur in the majority of patients.
Lots of agents were tried to prevent this, but there is not a routine treatment modality yet.
The aim of this study was to evaluate the otoprotective effect of sertraline, which is an antidepressant with neuroprotective effects, against cisplatin, in rats.
Design.
Experimental animal study.
Material and Methods.
Forty-eight rats were randomly separated in two groups as groups I and II.
Group I was identified as the control group and only a single dose of intraperitoneal cisplatin was administered.
In group II, in addition to cisplatin, sertraline was administered to the rats through an oral cannula for ten-day period.
Distortion product otoacoustic emission measurements were performed at the first day and the 10th day.
Results.
When the ototoxicity rates after cisplatin in group I and group II in distortion product otoacoustic emission measurements were compared, it was statistically significantly lower in group II in frequencies of 5652, 6165, 6726, 7336, and 7996 Hz (P<0.05).
Conclusion.
Sertraline seems to have a protective effect on cisplatin ototoxicity and could be used to prevent the ototoxicity and also to treat the depression that occurred in cancer patients together.
American Psychological Association (APA)
Ozturk, Murat& Ucar, Selcuk& Sarı, Fatih& Erdogan, Selvet& Topdag, Murat& Iseri, Mete. 2013. Possible Protective Effect of Sertraline against Cisplatin-Induced Ototoxicity: An Experimental Study. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1012463
Modern Language Association (MLA)
Ozturk, Murat…[et al.]. Possible Protective Effect of Sertraline against Cisplatin-Induced Ototoxicity: An Experimental Study. The Scientific World Journal No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1012463
American Medical Association (AMA)
Ozturk, Murat& Ucar, Selcuk& Sarı, Fatih& Erdogan, Selvet& Topdag, Murat& Iseri, Mete. Possible Protective Effect of Sertraline against Cisplatin-Induced Ototoxicity: An Experimental Study. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1012463
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1012463