Common and Specific Associations of Anti-SSARo60 and Anti-Ro52TRIM21 Antibodies in Systemic Lupus Erythematosus

الملخص EN

Little information exists about the association of anti-SSA/Ro60 and anti-Ro52/TRIM21 with systemic lupus erytematosus (SLE) features.

In this work, we analysed the associations of both anti-Ro reactivities with clinical and immunological manifestations in 141 SLE patients.

Photosensitivity and xerophtalmia/xerostomia were found to be positively associated with both anti-SSA/Ro60 (P=0.024 and P=0.019, resp.) and anti-Ro52/TRIM21 (P=0.026 and P=0.022, resp.).

In contrast, a negative association was detected regarding anti-phospholipid antibodies, anti-SSA/Ro60 having a stronger effect (P=0.014) than anti-Ro52/TRIM21.

Anti-SSA/Ro60 showed a specific positive association with hypocomplementemia (P=0.041), mainly with low C4 levels (P=0.008), whereas anti-Ro52/TRIM21 was found to be positively associated with Raynaud’s phenomenon (P=0.026) and cytopenia (P=0.048) and negatively associated with anti-dsDNA (P=0.013).

Lymphocytes are involved in the relationship between anti-Ro52/TRIM21 and cytopenia since positive patients showed lower cell levels than negative patients (P=0.036).

In conclusion, anti-SSA/Ro60 and anti-Ro52/TRIM21 showed both common and specific associations in SLE.

These data thus increase evidence of the different associations of the two anti-Ro specificities even in a particular disease.