Common and Specific Associations of Anti-SSARo60 and Anti-Ro52TRIM21 Antibodies in Systemic Lupus Erythematosus
Joint Authors
Menéndez, Aurora
Gómez, Jesús
Caminal-Montero, Luis
Díaz-López, José Bernardino
Cabezas-Rodríguez, Iván
Mozo, Lourdes
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Little information exists about the association of anti-SSA/Ro60 and anti-Ro52/TRIM21 with systemic lupus erytematosus (SLE) features.
In this work, we analysed the associations of both anti-Ro reactivities with clinical and immunological manifestations in 141 SLE patients.
Photosensitivity and xerophtalmia/xerostomia were found to be positively associated with both anti-SSA/Ro60 (P=0.024 and P=0.019, resp.) and anti-Ro52/TRIM21 (P=0.026 and P=0.022, resp.).
In contrast, a negative association was detected regarding anti-phospholipid antibodies, anti-SSA/Ro60 having a stronger effect (P=0.014) than anti-Ro52/TRIM21.
Anti-SSA/Ro60 showed a specific positive association with hypocomplementemia (P=0.041), mainly with low C4 levels (P=0.008), whereas anti-Ro52/TRIM21 was found to be positively associated with Raynaud’s phenomenon (P=0.026) and cytopenia (P=0.048) and negatively associated with anti-dsDNA (P=0.013).
Lymphocytes are involved in the relationship between anti-Ro52/TRIM21 and cytopenia since positive patients showed lower cell levels than negative patients (P=0.036).
In conclusion, anti-SSA/Ro60 and anti-Ro52/TRIM21 showed both common and specific associations in SLE.
These data thus increase evidence of the different associations of the two anti-Ro specificities even in a particular disease.
American Psychological Association (APA)
Menéndez, Aurora& Gómez, Jesús& Caminal-Montero, Luis& Díaz-López, José Bernardino& Cabezas-Rodríguez, Iván& Mozo, Lourdes. 2013. Common and Specific Associations of Anti-SSARo60 and Anti-Ro52TRIM21 Antibodies in Systemic Lupus Erythematosus. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1012970
Modern Language Association (MLA)
Menéndez, Aurora…[et al.]. Common and Specific Associations of Anti-SSARo60 and Anti-Ro52TRIM21 Antibodies in Systemic Lupus Erythematosus. The Scientific World Journal No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1012970
American Medical Association (AMA)
Menéndez, Aurora& Gómez, Jesús& Caminal-Montero, Luis& Díaz-López, José Bernardino& Cabezas-Rodríguez, Iván& Mozo, Lourdes. Common and Specific Associations of Anti-SSARo60 and Anti-Ro52TRIM21 Antibodies in Systemic Lupus Erythematosus. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1012970
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1012970