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Chemokines Referee Inflammation within the Central Nervous System during Infection and Disease
المؤلفون المشاركون
Durrant, Douglas M.
Williams, Jessica L.
Daniels, Brian P.
Klein, Robyn S.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The discovery that chemokines and their receptors are expressed by a variety of cell types within the normal adult central nervous system (CNS) has led to an expansion of their repertoire as molecular interfaces between the immune and nervous systems.
Thus, CNS chemokines are now divided into those molecules that regulate inflammatory cell migration into the CNS and those that initiate CNS repair from inflammation-mediated tissue damage.
Work in our laboratory throughout the past decade has sought to elucidate how chemokines coordinate leukocyte entry and interactions at CNS endothelial barriers, under both homeostatic and inflammatory conditions, and how they promote repair within the CNS parenchyma.
These studies have identified several chemokines, including CXCL12 and CXCL10, as critical regulators of leukocyte migration from perivascular locations.
CXCL12 additionally plays an essential role in promoting remyelination of injured white matter.
In both scenarios we have shown that chemokines serve as molecular links between inflammatory mediators and other effector molecules involved in neuroprotective processes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Durrant, Douglas M.& Williams, Jessica L.& Daniels, Brian P.& Klein, Robyn S.. 2014. Chemokines Referee Inflammation within the Central Nervous System during Infection and Disease. Advances in Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1015502
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Durrant, Douglas M.…[et al.]. Chemokines Referee Inflammation within the Central Nervous System during Infection and Disease. Advances in Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1015502
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Durrant, Douglas M.& Williams, Jessica L.& Daniels, Brian P.& Klein, Robyn S.. Chemokines Referee Inflammation within the Central Nervous System during Infection and Disease. Advances in Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1015502
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1015502
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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