Chemokines Referee Inflammation within the Central Nervous System during Infection and Disease
Joint Authors
Durrant, Douglas M.
Williams, Jessica L.
Daniels, Brian P.
Klein, Robyn S.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The discovery that chemokines and their receptors are expressed by a variety of cell types within the normal adult central nervous system (CNS) has led to an expansion of their repertoire as molecular interfaces between the immune and nervous systems.
Thus, CNS chemokines are now divided into those molecules that regulate inflammatory cell migration into the CNS and those that initiate CNS repair from inflammation-mediated tissue damage.
Work in our laboratory throughout the past decade has sought to elucidate how chemokines coordinate leukocyte entry and interactions at CNS endothelial barriers, under both homeostatic and inflammatory conditions, and how they promote repair within the CNS parenchyma.
These studies have identified several chemokines, including CXCL12 and CXCL10, as critical regulators of leukocyte migration from perivascular locations.
CXCL12 additionally plays an essential role in promoting remyelination of injured white matter.
In both scenarios we have shown that chemokines serve as molecular links between inflammatory mediators and other effector molecules involved in neuroprotective processes.
American Psychological Association (APA)
Durrant, Douglas M.& Williams, Jessica L.& Daniels, Brian P.& Klein, Robyn S.. 2014. Chemokines Referee Inflammation within the Central Nervous System during Infection and Disease. Advances in Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1015502
Modern Language Association (MLA)
Durrant, Douglas M.…[et al.]. Chemokines Referee Inflammation within the Central Nervous System during Infection and Disease. Advances in Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1015502
American Medical Association (AMA)
Durrant, Douglas M.& Williams, Jessica L.& Daniels, Brian P.& Klein, Robyn S.. Chemokines Referee Inflammation within the Central Nervous System during Infection and Disease. Advances in Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1015502
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1015502