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The Preventive Effects of Diminazene Aceturate in Renal IschemiaReperfusion Injury in Male and Female Rats
المؤلفون المشاركون
Malek, Maryam
Nematbakhsh, Mehdi
المصدر
Advances in Preventive Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-13
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Angiotensin-converting enzyme 2/angiotensin (1-7)/Mas receptor (ACE2/Ang-1-7/MasR) appears to counteract most of the deleterious actions of angiotensin-converting enzyme/angiotensin II/angiotensin II receptor 1 (ACE/Ang II/AT1R) in renal ischemia/reperfusion (I/R) injury but ACE2 activity and its levels are sexually dimorphic in the kidney.
This study was designed to evaluate the effects of activation endogenous ACE2 using the diminazene aceturate (DIZE) in renal I/R injury in male and female rats.
Methods.
36 Wistar rats were divided into two groups of male and female and each group distinct to three subgroups ( n = 6 ).
I/R group was subjected to 45 min of bilateral ischemia and 24 h of reperfusion, while treatment group received DIZE (15 mg/kg/day) for three days before the induction of I/R.
The other group was assigned as the sham-operated group.
Results.
DIZE treatment in male rats caused a significant decrease in blood urea nitrogen (BUN), creatinine, liver functional indices, serum malondialdehyde (MDA), and increase kidney nitrite levels ( P < 0.05 ), and in female rats a significant increase in creatinine and decrease serum nitrite levels compared to the I/R group ( P < 0.05 ).
Conclusions.
DIZE may protect the male kidney from renal I/RI through antioxidant activity and elevation of circulating nitrite level.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Malek, Maryam& Nematbakhsh, Mehdi. 2014. The Preventive Effects of Diminazene Aceturate in Renal IschemiaReperfusion Injury in Male and Female Rats. Advances in Preventive Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016002
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Malek, Maryam& Nematbakhsh, Mehdi. The Preventive Effects of Diminazene Aceturate in Renal IschemiaReperfusion Injury in Male and Female Rats. Advances in Preventive Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1016002
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Malek, Maryam& Nematbakhsh, Mehdi. The Preventive Effects of Diminazene Aceturate in Renal IschemiaReperfusion Injury in Male and Female Rats. Advances in Preventive Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016002
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1016002
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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