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The Preventive Effects of Diminazene Aceturate in Renal IschemiaReperfusion Injury in Male and Female Rats
Joint Authors
Malek, Maryam
Nematbakhsh, Mehdi
Source
Advances in Preventive Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Angiotensin-converting enzyme 2/angiotensin (1-7)/Mas receptor (ACE2/Ang-1-7/MasR) appears to counteract most of the deleterious actions of angiotensin-converting enzyme/angiotensin II/angiotensin II receptor 1 (ACE/Ang II/AT1R) in renal ischemia/reperfusion (I/R) injury but ACE2 activity and its levels are sexually dimorphic in the kidney.
This study was designed to evaluate the effects of activation endogenous ACE2 using the diminazene aceturate (DIZE) in renal I/R injury in male and female rats.
Methods.
36 Wistar rats were divided into two groups of male and female and each group distinct to three subgroups ( n = 6 ).
I/R group was subjected to 45 min of bilateral ischemia and 24 h of reperfusion, while treatment group received DIZE (15 mg/kg/day) for three days before the induction of I/R.
The other group was assigned as the sham-operated group.
Results.
DIZE treatment in male rats caused a significant decrease in blood urea nitrogen (BUN), creatinine, liver functional indices, serum malondialdehyde (MDA), and increase kidney nitrite levels ( P < 0.05 ), and in female rats a significant increase in creatinine and decrease serum nitrite levels compared to the I/R group ( P < 0.05 ).
Conclusions.
DIZE may protect the male kidney from renal I/RI through antioxidant activity and elevation of circulating nitrite level.
American Psychological Association (APA)
Malek, Maryam& Nematbakhsh, Mehdi. 2014. The Preventive Effects of Diminazene Aceturate in Renal IschemiaReperfusion Injury in Male and Female Rats. Advances in Preventive Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016002
Modern Language Association (MLA)
Malek, Maryam& Nematbakhsh, Mehdi. The Preventive Effects of Diminazene Aceturate in Renal IschemiaReperfusion Injury in Male and Female Rats. Advances in Preventive Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1016002
American Medical Association (AMA)
Malek, Maryam& Nematbakhsh, Mehdi. The Preventive Effects of Diminazene Aceturate in Renal IschemiaReperfusion Injury in Male and Female Rats. Advances in Preventive Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016002
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016002