Teratogenic Effects of Coadministration of Fluoxetine and Olanzapine on Rat Fetuses
المؤلفون المشاركون
Sistany, Narges
Giorgi, Mario
Takzare, Nasrin
Sheykhi, Mehdi
Bakhtiarian, Azam
Nikoui, Vahid
Jazaeri, Farahnaz
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-16
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Depression during pregnancy is a relatively common problem.
Since little is known about the teratogenic effects of concomitant administration of fluoxetine and olanzapine during the organogenesis period, the aim of the present study was to evaluate the teratogenic effects of coadministration of fluoxetine and olanzapine on rat fetuses.
Method.
Forty-two pregnant rats were divided into seven groups, randomly.
The first group received 0.5 mL of normal saline as the control.
The second and third groups received fluoxetine at doses of 9 mg/kg and 18 mg/kg, respectively.
Olanzapine was injected at 3 mg/kg and 6 mg/kg to the fourth and fifth groups, respectively.
The sixth group received 9 mg/kg fluoxetine and 3 mg/kg olanzapine.
Finally, the seventh group was administrated with fluoxetine and olanzapine at 18 mg/kg and 6 mg/kg, respectively.
Drugs were injected intraperitoneally between day eight and day 15 of the pregnancy.
On the 17th day of pregnancy, the fetuses were removed and micro-/macroscopically studied.
Results.
Fetuses of rats receiving high doses of these drugs showed a significant rate of cleft palate development, premature eyelid opening and torsion anomalies, compared to the control group ( P ≤ 0.01 ).
It is concluded that these drugs can lead to teratogenicity, so their concomitant use during pregnancy should be avoided, or if necessary their doses must be decreased.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bakhtiarian, Azam& Takzare, Nasrin& Sheykhi, Mehdi& Sistany, Narges& Jazaeri, Farahnaz& Giorgi, Mario…[et al.]. 2014. Teratogenic Effects of Coadministration of Fluoxetine and Olanzapine on Rat Fetuses. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1016005
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bakhtiarian, Azam…[et al.]. Teratogenic Effects of Coadministration of Fluoxetine and Olanzapine on Rat Fetuses. Advances in Pharmacological and Pharmaceutical Sciences No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1016005
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bakhtiarian, Azam& Takzare, Nasrin& Sheykhi, Mehdi& Sistany, Narges& Jazaeri, Farahnaz& Giorgi, Mario…[et al.]. Teratogenic Effects of Coadministration of Fluoxetine and Olanzapine on Rat Fetuses. Advances in Pharmacological and Pharmaceutical Sciences. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1016005
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1016005
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر