Teratogenic Effects of Coadministration of Fluoxetine and Olanzapine on Rat Fetuses
Joint Authors
Sistany, Narges
Giorgi, Mario
Takzare, Nasrin
Sheykhi, Mehdi
Bakhtiarian, Azam
Nikoui, Vahid
Jazaeri, Farahnaz
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Depression during pregnancy is a relatively common problem.
Since little is known about the teratogenic effects of concomitant administration of fluoxetine and olanzapine during the organogenesis period, the aim of the present study was to evaluate the teratogenic effects of coadministration of fluoxetine and olanzapine on rat fetuses.
Method.
Forty-two pregnant rats were divided into seven groups, randomly.
The first group received 0.5 mL of normal saline as the control.
The second and third groups received fluoxetine at doses of 9 mg/kg and 18 mg/kg, respectively.
Olanzapine was injected at 3 mg/kg and 6 mg/kg to the fourth and fifth groups, respectively.
The sixth group received 9 mg/kg fluoxetine and 3 mg/kg olanzapine.
Finally, the seventh group was administrated with fluoxetine and olanzapine at 18 mg/kg and 6 mg/kg, respectively.
Drugs were injected intraperitoneally between day eight and day 15 of the pregnancy.
On the 17th day of pregnancy, the fetuses were removed and micro-/macroscopically studied.
Results.
Fetuses of rats receiving high doses of these drugs showed a significant rate of cleft palate development, premature eyelid opening and torsion anomalies, compared to the control group ( P ≤ 0.01 ).
It is concluded that these drugs can lead to teratogenicity, so their concomitant use during pregnancy should be avoided, or if necessary their doses must be decreased.
American Psychological Association (APA)
Bakhtiarian, Azam& Takzare, Nasrin& Sheykhi, Mehdi& Sistany, Narges& Jazaeri, Farahnaz& Giorgi, Mario…[et al.]. 2014. Teratogenic Effects of Coadministration of Fluoxetine and Olanzapine on Rat Fetuses. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1016005
Modern Language Association (MLA)
Bakhtiarian, Azam…[et al.]. Teratogenic Effects of Coadministration of Fluoxetine and Olanzapine on Rat Fetuses. Advances in Pharmacological and Pharmaceutical Sciences No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1016005
American Medical Association (AMA)
Bakhtiarian, Azam& Takzare, Nasrin& Sheykhi, Mehdi& Sistany, Narges& Jazaeri, Farahnaz& Giorgi, Mario…[et al.]. Teratogenic Effects of Coadministration of Fluoxetine and Olanzapine on Rat Fetuses. Advances in Pharmacological and Pharmaceutical Sciences. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1016005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016005