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Structural Differences Observed in Arboviruses of the Alphavirus and Flavivirus Genera
المؤلفون المشاركون
Hernandez, Raquel
Brown, Dennis T.
Paredes, Angel
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-24، 24ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-16
دولة النشر
مصر
عدد الصفحات
24
التخصصات الرئيسية
الملخص EN
Arthropod borne viruses have developed a complex life cycle adapted to alternate between insect and vertebrate hosts.
These arthropod-borne viruses belong mainly to the families Togaviridae, Flaviviridae, and Bunyaviridae.
This group of viruses contains many pathogens that cause febrile, hemorrhagic, and encephalitic disease or arthritic symptoms which can be persistent.
It has been appreciated for many years that these viruses were evolutionarily adapted to function in the highly divergent cellular environments of both insect and mammalian phyla.
These viruses are hybrid in nature, containing viral-encoded RNA and proteins which are glycosylated by the host and encapsulate viral nucleocapsids in the context of a host-derived membrane.
From a structural perspective, these virus particles are macromolecular machines adapted in design to assemble into a packaging and delivery system for the virus genome and, only when associated with the conditions appropriate for a productive infection, to disassemble and deliver the RNA cargo.
It was initially assumed that the structures of the virus from both hosts were equivalent.
New evidence that alphaviruses and flaviviruses can exist in more than one conformation postenvelopment will be discussed in this review.
The data are limited but should refocus the field of structural biology on the metastable nature of these viruses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hernandez, Raquel& Brown, Dennis T.& Paredes, Angel. 2014. Structural Differences Observed in Arboviruses of the Alphavirus and Flavivirus Genera. Advances in Virology،Vol. 2014, no. 2014, pp.1-24.
https://search.emarefa.net/detail/BIM-1016061
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hernandez, Raquel…[et al.]. Structural Differences Observed in Arboviruses of the Alphavirus and Flavivirus Genera. Advances in Virology No. 2014 (2014), pp.1-24.
https://search.emarefa.net/detail/BIM-1016061
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hernandez, Raquel& Brown, Dennis T.& Paredes, Angel. Structural Differences Observed in Arboviruses of the Alphavirus and Flavivirus Genera. Advances in Virology. 2014. Vol. 2014, no. 2014, pp.1-24.
https://search.emarefa.net/detail/BIM-1016061
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1016061
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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