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Structural Differences Observed in Arboviruses of the Alphavirus and Flavivirus Genera
Joint Authors
Hernandez, Raquel
Brown, Dennis T.
Paredes, Angel
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-24, 24 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-16
Country of Publication
Egypt
No. of Pages
24
Main Subjects
Abstract EN
Arthropod borne viruses have developed a complex life cycle adapted to alternate between insect and vertebrate hosts.
These arthropod-borne viruses belong mainly to the families Togaviridae, Flaviviridae, and Bunyaviridae.
This group of viruses contains many pathogens that cause febrile, hemorrhagic, and encephalitic disease or arthritic symptoms which can be persistent.
It has been appreciated for many years that these viruses were evolutionarily adapted to function in the highly divergent cellular environments of both insect and mammalian phyla.
These viruses are hybrid in nature, containing viral-encoded RNA and proteins which are glycosylated by the host and encapsulate viral nucleocapsids in the context of a host-derived membrane.
From a structural perspective, these virus particles are macromolecular machines adapted in design to assemble into a packaging and delivery system for the virus genome and, only when associated with the conditions appropriate for a productive infection, to disassemble and deliver the RNA cargo.
It was initially assumed that the structures of the virus from both hosts were equivalent.
New evidence that alphaviruses and flaviviruses can exist in more than one conformation postenvelopment will be discussed in this review.
The data are limited but should refocus the field of structural biology on the metastable nature of these viruses.
American Psychological Association (APA)
Hernandez, Raquel& Brown, Dennis T.& Paredes, Angel. 2014. Structural Differences Observed in Arboviruses of the Alphavirus and Flavivirus Genera. Advances in Virology،Vol. 2014, no. 2014, pp.1-24.
https://search.emarefa.net/detail/BIM-1016061
Modern Language Association (MLA)
Hernandez, Raquel…[et al.]. Structural Differences Observed in Arboviruses of the Alphavirus and Flavivirus Genera. Advances in Virology No. 2014 (2014), pp.1-24.
https://search.emarefa.net/detail/BIM-1016061
American Medical Association (AMA)
Hernandez, Raquel& Brown, Dennis T.& Paredes, Angel. Structural Differences Observed in Arboviruses of the Alphavirus and Flavivirus Genera. Advances in Virology. 2014. Vol. 2014, no. 2014, pp.1-24.
https://search.emarefa.net/detail/BIM-1016061
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016061