Human Lung Cancer Cell Line A-549 ATCC Is Differentially Affected by Supranutritional Organic and Inorganic Selenium
المؤلفون المشاركون
Flores Villavicencio, Lérida Liss
Cruz-Jiménez, Gustavo
Barbosa-Sabanero, Gloria
Kornhauser-Araujo, Carlos
Mendoza-Garrido, M. Eugenia
de la Rosa, Guadalupe
Sabanero-López, Myrna
المصدر
Bioinorganic Chemistry and Applications
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-12
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The effects of organic and inorganic forms of selenium (Se) on human cells have been extensively studied for nutritional concentrations; however, to date, little is known about the potential toxicity at supranutritional levels.
In the present study we determined the effects of sodium selenite (SSe) and selenomethionine (SeMet) on cell growth and intracellular structures in lung cancer cells exposed at Se concentrations between 0 and 3 mM.
Our results showed that SSe affected cell growth more rapidly than SeMet (24 h and 48 h, resp.).
After 24 h of cells exposure to 0.5, 1.5, and 3 mM SSe, cell growth was reduced by 10, 50, and 60%, as compared to controls.
After 48 h, nuclear fragmentation was evident in cells exposed to SSe, suggesting an induction to cell death.
In contrast, SeMet did not affect cell proliferation, and the cells were phenotypically similar to controls.
Microtubules and microfilaments structures were also affected by both Se compounds, again SSe being more toxic than SeMet.
To our knowledge, this is the first report on the differential effects of organic and inorganic Se in supranutritional levels in lung cancer cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Flores Villavicencio, Lérida Liss& Cruz-Jiménez, Gustavo& Barbosa-Sabanero, Gloria& Kornhauser-Araujo, Carlos& Mendoza-Garrido, M. Eugenia& de la Rosa, Guadalupe…[et al.]. 2014. Human Lung Cancer Cell Line A-549 ATCC Is Differentially Affected by Supranutritional Organic and Inorganic Selenium. Bioinorganic Chemistry and Applications،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1016084
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Flores Villavicencio, Lérida Liss…[et al.]. Human Lung Cancer Cell Line A-549 ATCC Is Differentially Affected by Supranutritional Organic and Inorganic Selenium. Bioinorganic Chemistry and Applications No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1016084
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Flores Villavicencio, Lérida Liss& Cruz-Jiménez, Gustavo& Barbosa-Sabanero, Gloria& Kornhauser-Araujo, Carlos& Mendoza-Garrido, M. Eugenia& de la Rosa, Guadalupe…[et al.]. Human Lung Cancer Cell Line A-549 ATCC Is Differentially Affected by Supranutritional Organic and Inorganic Selenium. Bioinorganic Chemistry and Applications. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1016084
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1016084
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر