Human Lung Cancer Cell Line A-549 ATCC Is Differentially Affected by Supranutritional Organic and Inorganic Selenium

المؤلفون المشاركون

Flores Villavicencio, Lérida Liss
Cruz-Jiménez, Gustavo
Barbosa-Sabanero, Gloria
Kornhauser-Araujo, Carlos
Mendoza-Garrido, M. Eugenia
de la Rosa, Guadalupe
Sabanero-López, Myrna

المصدر

Bioinorganic Chemistry and Applications

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-11-12

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الأحياء

الملخص EN

The effects of organic and inorganic forms of selenium (Se) on human cells have been extensively studied for nutritional concentrations; however, to date, little is known about the potential toxicity at supranutritional levels.

In the present study we determined the effects of sodium selenite (SSe) and selenomethionine (SeMet) on cell growth and intracellular structures in lung cancer cells exposed at Se concentrations between 0 and 3 mM.

Our results showed that SSe affected cell growth more rapidly than SeMet (24 h and 48 h, resp.).

After 24 h of cells exposure to 0.5, 1.5, and 3 mM SSe, cell growth was reduced by 10, 50, and 60%, as compared to controls.

After 48 h, nuclear fragmentation was evident in cells exposed to SSe, suggesting an induction to cell death.

In contrast, SeMet did not affect cell proliferation, and the cells were phenotypically similar to controls.

Microtubules and microfilaments structures were also affected by both Se compounds, again SSe being more toxic than SeMet.

To our knowledge, this is the first report on the differential effects of organic and inorganic Se in supranutritional levels in lung cancer cells.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Flores Villavicencio, Lérida Liss& Cruz-Jiménez, Gustavo& Barbosa-Sabanero, Gloria& Kornhauser-Araujo, Carlos& Mendoza-Garrido, M. Eugenia& de la Rosa, Guadalupe…[et al.]. 2014. Human Lung Cancer Cell Line A-549 ATCC Is Differentially Affected by Supranutritional Organic and Inorganic Selenium. Bioinorganic Chemistry and Applications،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1016084

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Flores Villavicencio, Lérida Liss…[et al.]. Human Lung Cancer Cell Line A-549 ATCC Is Differentially Affected by Supranutritional Organic and Inorganic Selenium. Bioinorganic Chemistry and Applications No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1016084

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Flores Villavicencio, Lérida Liss& Cruz-Jiménez, Gustavo& Barbosa-Sabanero, Gloria& Kornhauser-Araujo, Carlos& Mendoza-Garrido, M. Eugenia& de la Rosa, Guadalupe…[et al.]. Human Lung Cancer Cell Line A-549 ATCC Is Differentially Affected by Supranutritional Organic and Inorganic Selenium. Bioinorganic Chemistry and Applications. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1016084

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1016084