Human Lung Cancer Cell Line A-549 ATCC Is Differentially Affected by Supranutritional Organic and Inorganic Selenium
Joint Authors
Flores Villavicencio, Lérida Liss
Cruz-Jiménez, Gustavo
Barbosa-Sabanero, Gloria
Kornhauser-Araujo, Carlos
Mendoza-Garrido, M. Eugenia
de la Rosa, Guadalupe
Sabanero-López, Myrna
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The effects of organic and inorganic forms of selenium (Se) on human cells have been extensively studied for nutritional concentrations; however, to date, little is known about the potential toxicity at supranutritional levels.
In the present study we determined the effects of sodium selenite (SSe) and selenomethionine (SeMet) on cell growth and intracellular structures in lung cancer cells exposed at Se concentrations between 0 and 3 mM.
Our results showed that SSe affected cell growth more rapidly than SeMet (24 h and 48 h, resp.).
After 24 h of cells exposure to 0.5, 1.5, and 3 mM SSe, cell growth was reduced by 10, 50, and 60%, as compared to controls.
After 48 h, nuclear fragmentation was evident in cells exposed to SSe, suggesting an induction to cell death.
In contrast, SeMet did not affect cell proliferation, and the cells were phenotypically similar to controls.
Microtubules and microfilaments structures were also affected by both Se compounds, again SSe being more toxic than SeMet.
To our knowledge, this is the first report on the differential effects of organic and inorganic Se in supranutritional levels in lung cancer cells.
American Psychological Association (APA)
Flores Villavicencio, Lérida Liss& Cruz-Jiménez, Gustavo& Barbosa-Sabanero, Gloria& Kornhauser-Araujo, Carlos& Mendoza-Garrido, M. Eugenia& de la Rosa, Guadalupe…[et al.]. 2014. Human Lung Cancer Cell Line A-549 ATCC Is Differentially Affected by Supranutritional Organic and Inorganic Selenium. Bioinorganic Chemistry and Applications،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1016084
Modern Language Association (MLA)
Flores Villavicencio, Lérida Liss…[et al.]. Human Lung Cancer Cell Line A-549 ATCC Is Differentially Affected by Supranutritional Organic and Inorganic Selenium. Bioinorganic Chemistry and Applications No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1016084
American Medical Association (AMA)
Flores Villavicencio, Lérida Liss& Cruz-Jiménez, Gustavo& Barbosa-Sabanero, Gloria& Kornhauser-Araujo, Carlos& Mendoza-Garrido, M. Eugenia& de la Rosa, Guadalupe…[et al.]. Human Lung Cancer Cell Line A-549 ATCC Is Differentially Affected by Supranutritional Organic and Inorganic Selenium. Bioinorganic Chemistry and Applications. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1016084
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016084