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Evolution of Network Biomarkers from Early to Late Stage Bladder Cancer Samples
المؤلفون المشاركون
Chen, Bor-Sen
Wong, Yung-Hao
Li, Cheng-Wei
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-23، 23ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-18
دولة النشر
مصر
عدد الصفحات
23
التخصصات الرئيسية
الملخص EN
We use a systems biology approach to construct protein-protein interaction networks (PPINs) for early and late stage bladder cancer.
By comparing the networks of these two stages, we find that both networks showed very significantly different mechanisms.
To obtain the differential network structures between cancer and noncancer PPINs, we constructed cancer PPIN and noncancer PPIN network structures for the two bladder cancer stages using microarray data from cancer cells and their adjacent noncancer cells, respectively.
With their carcinogenesis relevance values (CRVs), we identified 152 and 50 significant proteins and their PPI networks (network markers) for early and late stage bladder cancer by statistical assessment.
To investigate the evolution of network biomarkers in the carcinogenesis process, primary pathway analysis showed that the significant pathways of early stage bladder cancer are related to ordinary cancer mechanisms, while the ribosome pathway and spliceosome pathway are most important for late stage bladder cancer.
Their only intersection is the ubiquitin mediated proteolysis pathway in the whole stage of bladder cancer.
The evolution of network biomarkers from early to late stage can reveal the carcinogenesis of bladder cancer.
The findings in this study are new clues specific to this study and give us a direction for targeted cancer therapy, and it should be validated in vivo or in vitro in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wong, Yung-Hao& Li, Cheng-Wei& Chen, Bor-Sen. 2014. Evolution of Network Biomarkers from Early to Late Stage Bladder Cancer Samples. BioMed Research International،Vol. 2014, no. 2014, pp.1-23.
https://search.emarefa.net/detail/BIM-1016109
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wong, Yung-Hao…[et al.]. Evolution of Network Biomarkers from Early to Late Stage Bladder Cancer Samples. BioMed Research International No. 2014 (2014), pp.1-23.
https://search.emarefa.net/detail/BIM-1016109
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wong, Yung-Hao& Li, Cheng-Wei& Chen, Bor-Sen. Evolution of Network Biomarkers from Early to Late Stage Bladder Cancer Samples. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-23.
https://search.emarefa.net/detail/BIM-1016109
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1016109
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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