Evolution of Network Biomarkers from Early to Late Stage Bladder Cancer Samples
Joint Authors
Chen, Bor-Sen
Wong, Yung-Hao
Li, Cheng-Wei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-18
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
We use a systems biology approach to construct protein-protein interaction networks (PPINs) for early and late stage bladder cancer.
By comparing the networks of these two stages, we find that both networks showed very significantly different mechanisms.
To obtain the differential network structures between cancer and noncancer PPINs, we constructed cancer PPIN and noncancer PPIN network structures for the two bladder cancer stages using microarray data from cancer cells and their adjacent noncancer cells, respectively.
With their carcinogenesis relevance values (CRVs), we identified 152 and 50 significant proteins and their PPI networks (network markers) for early and late stage bladder cancer by statistical assessment.
To investigate the evolution of network biomarkers in the carcinogenesis process, primary pathway analysis showed that the significant pathways of early stage bladder cancer are related to ordinary cancer mechanisms, while the ribosome pathway and spliceosome pathway are most important for late stage bladder cancer.
Their only intersection is the ubiquitin mediated proteolysis pathway in the whole stage of bladder cancer.
The evolution of network biomarkers from early to late stage can reveal the carcinogenesis of bladder cancer.
The findings in this study are new clues specific to this study and give us a direction for targeted cancer therapy, and it should be validated in vivo or in vitro in the future.
American Psychological Association (APA)
Wong, Yung-Hao& Li, Cheng-Wei& Chen, Bor-Sen. 2014. Evolution of Network Biomarkers from Early to Late Stage Bladder Cancer Samples. BioMed Research International،Vol. 2014, no. 2014, pp.1-23.
https://search.emarefa.net/detail/BIM-1016109
Modern Language Association (MLA)
Wong, Yung-Hao…[et al.]. Evolution of Network Biomarkers from Early to Late Stage Bladder Cancer Samples. BioMed Research International No. 2014 (2014), pp.1-23.
https://search.emarefa.net/detail/BIM-1016109
American Medical Association (AMA)
Wong, Yung-Hao& Li, Cheng-Wei& Chen, Bor-Sen. Evolution of Network Biomarkers from Early to Late Stage Bladder Cancer Samples. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-23.
https://search.emarefa.net/detail/BIM-1016109
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016109