BDNF Increases Survival and Neuronal Differentiation of Human Neural Precursor Cells Cotransplanted with a Nanofiber Gel to the Auditory Nerve in a Rat Model of Neuronal Damage
المؤلفون المشاركون
Jiao, Yu
Palmgren, Björn
Novozhilova, Ekaterina
Englund Johansson, Ulrica
Spieles-Engemann, Anne L.
Kale, Ajay
Stupp, Samuel I.
Olivius, Petri
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-26
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
|Objectives.
To study possible nerve regeneration of a damaged auditory nerve by the use of stem cell transplantation.
Methods.
We transplanted HNPCs to the rat AN trunk by the internal auditory meatus (IAM).
Furthermore, we studied if addition of BDNF affects survival and phenotypic differentiation of the grafted HNPCs.
A bioactive nanofiber gel (PA gel), in selected groups mixed with BDNF, was applied close to the implanted cells.
Before transplantation, all rats had been deafened by a round window niche application of β-bungarotoxin.
This neurotoxin causes a selective toxic destruction of the AN while keeping the hair cells intact.
Results.
Overall, HNPCs survived well for up to six weeks in all groups.
However, transplants receiving the BDNF-containing PA gel demonstrated significantly higher numbers of HNPCs and neuronal differentiation.
At six weeks, a majority of the HNPCs had migrated into the brain stem and differentiated.
Differentiated human cells as well as neurites were observed in the vicinity of the cochlear nucleus.
Conclusion.
Our results indicate that human neural precursor cells (HNPC) integration with host tissue benefits from additional brain derived neurotrophic factor (BDNF) treatment and that these cells appear to be good candidates for further regenerative studies on the auditory nerve (AN).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiao, Yu& Palmgren, Björn& Novozhilova, Ekaterina& Englund Johansson, Ulrica& Spieles-Engemann, Anne L.& Kale, Ajay…[et al.]. 2014. BDNF Increases Survival and Neuronal Differentiation of Human Neural Precursor Cells Cotransplanted with a Nanofiber Gel to the Auditory Nerve in a Rat Model of Neuronal Damage. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1016245
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiao, Yu…[et al.]. BDNF Increases Survival and Neuronal Differentiation of Human Neural Precursor Cells Cotransplanted with a Nanofiber Gel to the Auditory Nerve in a Rat Model of Neuronal Damage. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1016245
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiao, Yu& Palmgren, Björn& Novozhilova, Ekaterina& Englund Johansson, Ulrica& Spieles-Engemann, Anne L.& Kale, Ajay…[et al.]. BDNF Increases Survival and Neuronal Differentiation of Human Neural Precursor Cells Cotransplanted with a Nanofiber Gel to the Auditory Nerve in a Rat Model of Neuronal Damage. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1016245
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1016245
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر