DBC1CCAR2 and CCAR1 Are Largely Disordered Proteins that Have Evolved from One Common Ancestor
المؤلفون المشاركون
Brunquell, Jessica
Yuan, Jia
Erwin, Aqeela
Westerheide, Sandy D.
Xue, Bin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-09
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Deleted in breast cancer 1 (DBC1, CCAR2, KIAA1967) is a large, predominantly nuclear, multidomain protein that modulates gene expression by inhibiting several epigenetic modifiers, including the deacetylases SIRT1 and HDAC3, and the methyltransferase SUV39H1.
DBC1 shares many highly conserved protein domains with its paralog cell cycle and apoptosis regulator 1 (CCAR1, CARP-1).
In this study, we examined the full-length sequential and structural properties of DBC1 and CCAR1 from multiple species and correlated these properties with evolution.
Our data shows that the conserved domains shared between DBC1 and CCAR1 have similar domain structures, as well as similar patterns of predicted disorder in less-conserved intrinsically disordered regions.
Our analysis indicates similarities between DBC1, CCAR1, and the nematode protein lateral signaling target 3 (LST-3), suggesting that DBC1 and CCAR1 may have evolved from LST-3.
Our data also suggests that DBC1 emerged later in evolution than CCAR1.
DBC1 contains regions that show less conservation across species as compared to the same regions in CCAR1, suggesting a continuously evolving scenario for DBC1.
Overall, this study provides insight into the structure and evolution of DBC1 and CCAR1, which may impact future studies on the biological functions of these proteins.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Brunquell, Jessica& Yuan, Jia& Erwin, Aqeela& Westerheide, Sandy D.& Xue, Bin. 2014. DBC1CCAR2 and CCAR1 Are Largely Disordered Proteins that Have Evolved from One Common Ancestor. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1016284
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Brunquell, Jessica…[et al.]. DBC1CCAR2 and CCAR1 Are Largely Disordered Proteins that Have Evolved from One Common Ancestor. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1016284
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Brunquell, Jessica& Yuan, Jia& Erwin, Aqeela& Westerheide, Sandy D.& Xue, Bin. DBC1CCAR2 and CCAR1 Are Largely Disordered Proteins that Have Evolved from One Common Ancestor. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1016284
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1016284
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر