![](/images/graphics-bg.png)
DBC1CCAR2 and CCAR1 Are Largely Disordered Proteins that Have Evolved from One Common Ancestor
Joint Authors
Brunquell, Jessica
Yuan, Jia
Erwin, Aqeela
Westerheide, Sandy D.
Xue, Bin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-09
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Deleted in breast cancer 1 (DBC1, CCAR2, KIAA1967) is a large, predominantly nuclear, multidomain protein that modulates gene expression by inhibiting several epigenetic modifiers, including the deacetylases SIRT1 and HDAC3, and the methyltransferase SUV39H1.
DBC1 shares many highly conserved protein domains with its paralog cell cycle and apoptosis regulator 1 (CCAR1, CARP-1).
In this study, we examined the full-length sequential and structural properties of DBC1 and CCAR1 from multiple species and correlated these properties with evolution.
Our data shows that the conserved domains shared between DBC1 and CCAR1 have similar domain structures, as well as similar patterns of predicted disorder in less-conserved intrinsically disordered regions.
Our analysis indicates similarities between DBC1, CCAR1, and the nematode protein lateral signaling target 3 (LST-3), suggesting that DBC1 and CCAR1 may have evolved from LST-3.
Our data also suggests that DBC1 emerged later in evolution than CCAR1.
DBC1 contains regions that show less conservation across species as compared to the same regions in CCAR1, suggesting a continuously evolving scenario for DBC1.
Overall, this study provides insight into the structure and evolution of DBC1 and CCAR1, which may impact future studies on the biological functions of these proteins.
American Psychological Association (APA)
Brunquell, Jessica& Yuan, Jia& Erwin, Aqeela& Westerheide, Sandy D.& Xue, Bin. 2014. DBC1CCAR2 and CCAR1 Are Largely Disordered Proteins that Have Evolved from One Common Ancestor. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1016284
Modern Language Association (MLA)
Brunquell, Jessica…[et al.]. DBC1CCAR2 and CCAR1 Are Largely Disordered Proteins that Have Evolved from One Common Ancestor. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1016284
American Medical Association (AMA)
Brunquell, Jessica& Yuan, Jia& Erwin, Aqeela& Westerheide, Sandy D.& Xue, Bin. DBC1CCAR2 and CCAR1 Are Largely Disordered Proteins that Have Evolved from One Common Ancestor. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1016284
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016284