The Mcm2-7 Replicative Helicase: A Promising Chemotherapeutic Target
المؤلفون المشاركون
Simon, Nicholas E.
Schwacha, Anthony
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-28
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Numerous eukaryotic replication factors have served as chemotherapeutic targets.
One replication factor that has largely escaped drug development is the Mcm2-7 replicative helicase.
This heterohexameric complex forms the licensing system that assembles the replication machinery at origins during initiation, as well as the catalytic core of the CMG (Cdc45-Mcm2-7-GINS) helicase that unwinds DNA during elongation.
Emerging evidence suggests that Mcm2-7 is also part of the replication checkpoint, a quality control system that monitors and responds to DNA damage.
As the only replication factor required for both licensing and DNA unwinding, Mcm2-7 is a major cellular regulatory target with likely cancer relevance.
Mutations in at least one of the six MCM genes are particularly prevalent in squamous cell carcinomas of the lung, head and neck, and prostrate, and MCM mutations have been shown to cause cancer in mouse models.
Moreover various cellular regulatory proteins, including the Rb tumor suppressor family members, bind Mcm2-7 and inhibit its activity.
As a preliminary step toward drug development, several small molecule inhibitors that target Mcm2-7 have been recently discovered.
Both its structural complexity and essential role at the interface between DNA replication and its regulation make Mcm2-7 a potential chemotherapeutic target.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Simon, Nicholas E.& Schwacha, Anthony. 2014. The Mcm2-7 Replicative Helicase: A Promising Chemotherapeutic Target. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1016362
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Simon, Nicholas E.& Schwacha, Anthony. The Mcm2-7 Replicative Helicase: A Promising Chemotherapeutic Target. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1016362
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Simon, Nicholas E.& Schwacha, Anthony. The Mcm2-7 Replicative Helicase: A Promising Chemotherapeutic Target. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1016362
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1016362
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر