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The Mcm2-7 Replicative Helicase: A Promising Chemotherapeutic Target
Joint Authors
Simon, Nicholas E.
Schwacha, Anthony
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-28
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Numerous eukaryotic replication factors have served as chemotherapeutic targets.
One replication factor that has largely escaped drug development is the Mcm2-7 replicative helicase.
This heterohexameric complex forms the licensing system that assembles the replication machinery at origins during initiation, as well as the catalytic core of the CMG (Cdc45-Mcm2-7-GINS) helicase that unwinds DNA during elongation.
Emerging evidence suggests that Mcm2-7 is also part of the replication checkpoint, a quality control system that monitors and responds to DNA damage.
As the only replication factor required for both licensing and DNA unwinding, Mcm2-7 is a major cellular regulatory target with likely cancer relevance.
Mutations in at least one of the six MCM genes are particularly prevalent in squamous cell carcinomas of the lung, head and neck, and prostrate, and MCM mutations have been shown to cause cancer in mouse models.
Moreover various cellular regulatory proteins, including the Rb tumor suppressor family members, bind Mcm2-7 and inhibit its activity.
As a preliminary step toward drug development, several small molecule inhibitors that target Mcm2-7 have been recently discovered.
Both its structural complexity and essential role at the interface between DNA replication and its regulation make Mcm2-7 a potential chemotherapeutic target.
American Psychological Association (APA)
Simon, Nicholas E.& Schwacha, Anthony. 2014. The Mcm2-7 Replicative Helicase: A Promising Chemotherapeutic Target. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1016362
Modern Language Association (MLA)
Simon, Nicholas E.& Schwacha, Anthony. The Mcm2-7 Replicative Helicase: A Promising Chemotherapeutic Target. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1016362
American Medical Association (AMA)
Simon, Nicholas E.& Schwacha, Anthony. The Mcm2-7 Replicative Helicase: A Promising Chemotherapeutic Target. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1016362
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016362