The Mcm2-7 Replicative Helicase: A Promising Chemotherapeutic Target

Joint Authors

Simon, Nicholas E.
Schwacha, Anthony

Source

BioMed Research International

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-08-28

Country of Publication

Egypt

No. of Pages

14

Main Subjects

Medicine

Abstract EN

Numerous eukaryotic replication factors have served as chemotherapeutic targets.

One replication factor that has largely escaped drug development is the Mcm2-7 replicative helicase.

This heterohexameric complex forms the licensing system that assembles the replication machinery at origins during initiation, as well as the catalytic core of the CMG (Cdc45-Mcm2-7-GINS) helicase that unwinds DNA during elongation.

Emerging evidence suggests that Mcm2-7 is also part of the replication checkpoint, a quality control system that monitors and responds to DNA damage.

As the only replication factor required for both licensing and DNA unwinding, Mcm2-7 is a major cellular regulatory target with likely cancer relevance.

Mutations in at least one of the six MCM genes are particularly prevalent in squamous cell carcinomas of the lung, head and neck, and prostrate, and MCM mutations have been shown to cause cancer in mouse models.

Moreover various cellular regulatory proteins, including the Rb tumor suppressor family members, bind Mcm2-7 and inhibit its activity.

As a preliminary step toward drug development, several small molecule inhibitors that target Mcm2-7 have been recently discovered.

Both its structural complexity and essential role at the interface between DNA replication and its regulation make Mcm2-7 a potential chemotherapeutic target.

American Psychological Association (APA)

Simon, Nicholas E.& Schwacha, Anthony. 2014. The Mcm2-7 Replicative Helicase: A Promising Chemotherapeutic Target. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1016362

Modern Language Association (MLA)

Simon, Nicholas E.& Schwacha, Anthony. The Mcm2-7 Replicative Helicase: A Promising Chemotherapeutic Target. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1016362

American Medical Association (AMA)

Simon, Nicholas E.& Schwacha, Anthony. The Mcm2-7 Replicative Helicase: A Promising Chemotherapeutic Target. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1016362

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1016362