Proinflammatory Cytokines Correlate with Depression and Anxiety in Colorectal Cancer Patients
المؤلفون المشاركون
Oliveira Miranda, Diego
Soares de Lima, Taís Aparecida
Ribeiro Azevedo, Lucas
Feres, Omar
Ribeiro da Rocha, José Joaquim
Pereira-da-Silva, Gabriela
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-17
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
The objective of this study was to investigate whether serum cytokine levels correlate with depression and anxiety in colorectal cancer (CRC) patients.
Twenty patients hospitalized for surgical resection of CRC were included in the study group and twenty healthy volunteers comprised the control group.
Depression and anxiety were analyzed using the Hospital Anxiety and Depression Scale (HADS), and serum levels of IL-1β, IL-6, IL-8, IL-10, IL-12, TNF-α, and TGF-β were measured by Cytometric Bead Array.
We found that more than half of CRC patients presented clinically significant levels of anxiety or depression, and 65% of them manifested a combination of severe anxiety and depression.
CRC patients had increased serum levels of IL-1β, IL-6, IL-8, and TNF-α but lower IL-10 concentrations.
Correlation analysis between HADS score and cytokine levels revealed a positive association of anxiety and/or depression with IL-1β, IL-6, IL-8, and TNF-α and a negative correlation with IL-10.
These results indicate that circulating proinflammatory cytokines are involved in the pathophysiology of anxiety and depression in CRC patients.
A better understanding of the molecular mechanisms involved in these psychological disorders will allow the design of therapeutic interventions that lead to an improved quality of life and overall survival of CRC patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oliveira Miranda, Diego& Soares de Lima, Taís Aparecida& Ribeiro Azevedo, Lucas& Feres, Omar& Ribeiro da Rocha, José Joaquim& Pereira-da-Silva, Gabriela. 2014. Proinflammatory Cytokines Correlate with Depression and Anxiety in Colorectal Cancer Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1016528
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oliveira Miranda, Diego…[et al.]. Proinflammatory Cytokines Correlate with Depression and Anxiety in Colorectal Cancer Patients. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1016528
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oliveira Miranda, Diego& Soares de Lima, Taís Aparecida& Ribeiro Azevedo, Lucas& Feres, Omar& Ribeiro da Rocha, José Joaquim& Pereira-da-Silva, Gabriela. Proinflammatory Cytokines Correlate with Depression and Anxiety in Colorectal Cancer Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1016528
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1016528
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر