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Proinflammatory Cytokines Correlate with Depression and Anxiety in Colorectal Cancer Patients
Joint Authors
Oliveira Miranda, Diego
Soares de Lima, Taís Aparecida
Ribeiro Azevedo, Lucas
Feres, Omar
Ribeiro da Rocha, José Joaquim
Pereira-da-Silva, Gabriela
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The objective of this study was to investigate whether serum cytokine levels correlate with depression and anxiety in colorectal cancer (CRC) patients.
Twenty patients hospitalized for surgical resection of CRC were included in the study group and twenty healthy volunteers comprised the control group.
Depression and anxiety were analyzed using the Hospital Anxiety and Depression Scale (HADS), and serum levels of IL-1β, IL-6, IL-8, IL-10, IL-12, TNF-α, and TGF-β were measured by Cytometric Bead Array.
We found that more than half of CRC patients presented clinically significant levels of anxiety or depression, and 65% of them manifested a combination of severe anxiety and depression.
CRC patients had increased serum levels of IL-1β, IL-6, IL-8, and TNF-α but lower IL-10 concentrations.
Correlation analysis between HADS score and cytokine levels revealed a positive association of anxiety and/or depression with IL-1β, IL-6, IL-8, and TNF-α and a negative correlation with IL-10.
These results indicate that circulating proinflammatory cytokines are involved in the pathophysiology of anxiety and depression in CRC patients.
A better understanding of the molecular mechanisms involved in these psychological disorders will allow the design of therapeutic interventions that lead to an improved quality of life and overall survival of CRC patients.
American Psychological Association (APA)
Oliveira Miranda, Diego& Soares de Lima, Taís Aparecida& Ribeiro Azevedo, Lucas& Feres, Omar& Ribeiro da Rocha, José Joaquim& Pereira-da-Silva, Gabriela. 2014. Proinflammatory Cytokines Correlate with Depression and Anxiety in Colorectal Cancer Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1016528
Modern Language Association (MLA)
Oliveira Miranda, Diego…[et al.]. Proinflammatory Cytokines Correlate with Depression and Anxiety in Colorectal Cancer Patients. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1016528
American Medical Association (AMA)
Oliveira Miranda, Diego& Soares de Lima, Taís Aparecida& Ribeiro Azevedo, Lucas& Feres, Omar& Ribeiro da Rocha, José Joaquim& Pereira-da-Silva, Gabriela. Proinflammatory Cytokines Correlate with Depression and Anxiety in Colorectal Cancer Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1016528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016528