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The Nerve Growth Factor Signaling and Its Potential as Therapeutic Target for Glaucoma
المؤلفون المشاركون
Wang, Haitao
Wang, Rikang
Thrimawithana, Thilini
Little, Peter J.
Xu, Jiangping
Feng, Zhong-Ping
Zheng, Wenhua
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Neuroprotective therapies which focus on factors leading to retinal ganglion cells (RGCs) degeneration have been drawing more and more attention.
The beneficial effects of nerve growth factor (NGF) on the glaucoma have been recently suggested, but its effects on eye tissue are complex and controversial in various studies.
Recent clinical trials of systemically and topically administrated NGF demonstrate that NGF is effective in treating several ocular diseases, including glaucoma.
NGF has two receptors named high affinity NGF tyrosine kinase receptor TrkA and low affinity receptor p75NTR.
Both receptors exist in cells in retina like RGC (expressing TrkA) and glia cells (expressing p75NTR).
NGF functions by binding to TrkA or p75NTR alone or both together.
The binding of NGF to TrkA alone in RGC promotes RGC’s survival and proliferation through activation of TrkA and several prosurvival pathways.
In contrast, the binding of NGF to p75NTR leads to apoptosis although it also promotes survival in some cases.
Binding of NGF to both TrkA and p75NTR at the same time leads to survival in which p75NTR functions as a TrkA helping receptor.
This review discusses the current understanding of the NGF signaling in retina and the therapeutic implications in the treatment of glaucoma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Haitao& Wang, Rikang& Thrimawithana, Thilini& Little, Peter J.& Xu, Jiangping& Feng, Zhong-Ping…[et al.]. 2014. The Nerve Growth Factor Signaling and Its Potential as Therapeutic Target for Glaucoma. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016542
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Haitao…[et al.]. The Nerve Growth Factor Signaling and Its Potential as Therapeutic Target for Glaucoma. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1016542
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Haitao& Wang, Rikang& Thrimawithana, Thilini& Little, Peter J.& Xu, Jiangping& Feng, Zhong-Ping…[et al.]. The Nerve Growth Factor Signaling and Its Potential as Therapeutic Target for Glaucoma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016542
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1016542
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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