The Nerve Growth Factor Signaling and Its Potential as Therapeutic Target for Glaucoma
Joint Authors
Wang, Haitao
Wang, Rikang
Thrimawithana, Thilini
Little, Peter J.
Xu, Jiangping
Feng, Zhong-Ping
Zheng, Wenhua
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Neuroprotective therapies which focus on factors leading to retinal ganglion cells (RGCs) degeneration have been drawing more and more attention.
The beneficial effects of nerve growth factor (NGF) on the glaucoma have been recently suggested, but its effects on eye tissue are complex and controversial in various studies.
Recent clinical trials of systemically and topically administrated NGF demonstrate that NGF is effective in treating several ocular diseases, including glaucoma.
NGF has two receptors named high affinity NGF tyrosine kinase receptor TrkA and low affinity receptor p75NTR.
Both receptors exist in cells in retina like RGC (expressing TrkA) and glia cells (expressing p75NTR).
NGF functions by binding to TrkA or p75NTR alone or both together.
The binding of NGF to TrkA alone in RGC promotes RGC’s survival and proliferation through activation of TrkA and several prosurvival pathways.
In contrast, the binding of NGF to p75NTR leads to apoptosis although it also promotes survival in some cases.
Binding of NGF to both TrkA and p75NTR at the same time leads to survival in which p75NTR functions as a TrkA helping receptor.
This review discusses the current understanding of the NGF signaling in retina and the therapeutic implications in the treatment of glaucoma.
American Psychological Association (APA)
Wang, Haitao& Wang, Rikang& Thrimawithana, Thilini& Little, Peter J.& Xu, Jiangping& Feng, Zhong-Ping…[et al.]. 2014. The Nerve Growth Factor Signaling and Its Potential as Therapeutic Target for Glaucoma. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016542
Modern Language Association (MLA)
Wang, Haitao…[et al.]. The Nerve Growth Factor Signaling and Its Potential as Therapeutic Target for Glaucoma. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1016542
American Medical Association (AMA)
Wang, Haitao& Wang, Rikang& Thrimawithana, Thilini& Little, Peter J.& Xu, Jiangping& Feng, Zhong-Ping…[et al.]. The Nerve Growth Factor Signaling and Its Potential as Therapeutic Target for Glaucoma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016542
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016542