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Propofol Infusion Syndrome: A Retrospective Analysis at a Level 1 Trauma Center
المؤلفون المشاركون
Diaz, James H.
Prabhakar, Amit
Urman, Richard D.
Kaye, Alan David
المصدر
Critical Care Research and Practice
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-16
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
|Objectives.
The propofol infusion syndrome (PRIS), a rare, often fatal, condition of unknown etiology, is defined by development of lipemic serum, metabolic acidosis, rhabdomyolysis, hepatomegaly, cardiac arrhythmias, and acute renal failure.
Methods.
To identify risk factors for and biomarkers of PRIS, a retrospective chart review of all possible PRIS cases during a 1-year period was conducted at a level 1 trauma hospital in ICU patients over 18 years of age receiving continuous propofol infusions for ≥3 days.
Additional study inclusion criteria included vasopressor support and monitoring of serum triglycerides and creatinine.
Results.
Seventy-two patients, 61 males (84.7%) and 11 females (15.3%), satisfied study inclusion criteria; and of these, 3 males met the study definition for PRIS, with 1 case fatality.
PRIS incidence was 4.1% with a case-fatality rate of 33%.
The mean duration of propofol infusion was 6.96 days.
A positive linear correlation was observed between increasing triglyceride levels and infusion duration, but no correlation was observed between increasing creatinine levels and infusion duration.
Conclusions.
Risk factors for PRIS were confirmed as high dose infusions over prolonged periods.
Increasing triglyceride levels may serve as reliable biomarkers of impending PRIS, if confirmed in future investigations with larger sample sizes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Diaz, James H.& Prabhakar, Amit& Urman, Richard D.& Kaye, Alan David. 2014. Propofol Infusion Syndrome: A Retrospective Analysis at a Level 1 Trauma Center. Critical Care Research and Practice،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1016692
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Diaz, James H.…[et al.]. Propofol Infusion Syndrome: A Retrospective Analysis at a Level 1 Trauma Center. Critical Care Research and Practice No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1016692
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Diaz, James H.& Prabhakar, Amit& Urman, Richard D.& Kaye, Alan David. Propofol Infusion Syndrome: A Retrospective Analysis at a Level 1 Trauma Center. Critical Care Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1016692
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1016692
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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