Propofol Infusion Syndrome: A Retrospective Analysis at a Level 1 Trauma Center
Joint Authors
Diaz, James H.
Prabhakar, Amit
Urman, Richard D.
Kaye, Alan David
Source
Critical Care Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
|Objectives.
The propofol infusion syndrome (PRIS), a rare, often fatal, condition of unknown etiology, is defined by development of lipemic serum, metabolic acidosis, rhabdomyolysis, hepatomegaly, cardiac arrhythmias, and acute renal failure.
Methods.
To identify risk factors for and biomarkers of PRIS, a retrospective chart review of all possible PRIS cases during a 1-year period was conducted at a level 1 trauma hospital in ICU patients over 18 years of age receiving continuous propofol infusions for ≥3 days.
Additional study inclusion criteria included vasopressor support and monitoring of serum triglycerides and creatinine.
Results.
Seventy-two patients, 61 males (84.7%) and 11 females (15.3%), satisfied study inclusion criteria; and of these, 3 males met the study definition for PRIS, with 1 case fatality.
PRIS incidence was 4.1% with a case-fatality rate of 33%.
The mean duration of propofol infusion was 6.96 days.
A positive linear correlation was observed between increasing triglyceride levels and infusion duration, but no correlation was observed between increasing creatinine levels and infusion duration.
Conclusions.
Risk factors for PRIS were confirmed as high dose infusions over prolonged periods.
Increasing triglyceride levels may serve as reliable biomarkers of impending PRIS, if confirmed in future investigations with larger sample sizes.
American Psychological Association (APA)
Diaz, James H.& Prabhakar, Amit& Urman, Richard D.& Kaye, Alan David. 2014. Propofol Infusion Syndrome: A Retrospective Analysis at a Level 1 Trauma Center. Critical Care Research and Practice،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1016692
Modern Language Association (MLA)
Diaz, James H.…[et al.]. Propofol Infusion Syndrome: A Retrospective Analysis at a Level 1 Trauma Center. Critical Care Research and Practice No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1016692
American Medical Association (AMA)
Diaz, James H.& Prabhakar, Amit& Urman, Richard D.& Kaye, Alan David. Propofol Infusion Syndrome: A Retrospective Analysis at a Level 1 Trauma Center. Critical Care Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1016692
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016692