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A Challenge for Diagnosing Acute Liver Injury with ConcomitantSequential Exposure to Multiple Drugs: Can Causality Assessment Scales Be Utilized to Identify the Offending Drug?
المؤلفون المشاركون
Lim, Roxanne
Choudry, Hassan
Conner, Kim
Karnsakul, Wikrom
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-24
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Drug-induced hepatotoxicity most commonly manifests as an acute hepatitis syndrome and remains the leading cause of drug-induced death/mortality and the primary reason for withdrawal of drugs from the pharmaceutical market.
We report a case of acute liver injury in a 12-year-old Hispanic boy, who received a series of five antibiotics (amoxicillin, ceftriaxone, vancomycin, ampicillin/sulbactam, and clindamycin) for cervical lymphadenitis/retropharyngeal cellulitis.
Histopathology of the liver biopsy specimen revealed acute cholestatic hepatitis.
All known causes of acute liver injury were appropriately excluded and (only) drug-induced liver injury was left as a cause of his cholestasis.
Liver-specific causality assessment scales such as Council for the International Organization of Medical Sciences/Roussel Uclaf Causality Assessment Method scoring system (CIOMS/RUCAM), Maria and Victorino scale, and Digestive Disease Week-Japan were applied to seek the most likely offending drug.
Although clindamycin is the most likely cause by clinical diagnosis, none of causality assessment scales aid in the diagnosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lim, Roxanne& Choudry, Hassan& Conner, Kim& Karnsakul, Wikrom. 2014. A Challenge for Diagnosing Acute Liver Injury with ConcomitantSequential Exposure to Multiple Drugs: Can Causality Assessment Scales Be Utilized to Identify the Offending Drug?. Case Reports in Pediatrics،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1017544
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lim, Roxanne…[et al.]. A Challenge for Diagnosing Acute Liver Injury with ConcomitantSequential Exposure to Multiple Drugs: Can Causality Assessment Scales Be Utilized to Identify the Offending Drug?. Case Reports in Pediatrics No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1017544
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lim, Roxanne& Choudry, Hassan& Conner, Kim& Karnsakul, Wikrom. A Challenge for Diagnosing Acute Liver Injury with ConcomitantSequential Exposure to Multiple Drugs: Can Causality Assessment Scales Be Utilized to Identify the Offending Drug?. Case Reports in Pediatrics. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1017544
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1017544
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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