A Challenge for Diagnosing Acute Liver Injury with ConcomitantSequential Exposure to Multiple Drugs: Can Causality Assessment Scales Be Utilized to Identify the Offending Drug?
Joint Authors
Lim, Roxanne
Choudry, Hassan
Conner, Kim
Karnsakul, Wikrom
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Drug-induced hepatotoxicity most commonly manifests as an acute hepatitis syndrome and remains the leading cause of drug-induced death/mortality and the primary reason for withdrawal of drugs from the pharmaceutical market.
We report a case of acute liver injury in a 12-year-old Hispanic boy, who received a series of five antibiotics (amoxicillin, ceftriaxone, vancomycin, ampicillin/sulbactam, and clindamycin) for cervical lymphadenitis/retropharyngeal cellulitis.
Histopathology of the liver biopsy specimen revealed acute cholestatic hepatitis.
All known causes of acute liver injury were appropriately excluded and (only) drug-induced liver injury was left as a cause of his cholestasis.
Liver-specific causality assessment scales such as Council for the International Organization of Medical Sciences/Roussel Uclaf Causality Assessment Method scoring system (CIOMS/RUCAM), Maria and Victorino scale, and Digestive Disease Week-Japan were applied to seek the most likely offending drug.
Although clindamycin is the most likely cause by clinical diagnosis, none of causality assessment scales aid in the diagnosis.
American Psychological Association (APA)
Lim, Roxanne& Choudry, Hassan& Conner, Kim& Karnsakul, Wikrom. 2014. A Challenge for Diagnosing Acute Liver Injury with ConcomitantSequential Exposure to Multiple Drugs: Can Causality Assessment Scales Be Utilized to Identify the Offending Drug?. Case Reports in Pediatrics،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1017544
Modern Language Association (MLA)
Lim, Roxanne…[et al.]. A Challenge for Diagnosing Acute Liver Injury with ConcomitantSequential Exposure to Multiple Drugs: Can Causality Assessment Scales Be Utilized to Identify the Offending Drug?. Case Reports in Pediatrics No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1017544
American Medical Association (AMA)
Lim, Roxanne& Choudry, Hassan& Conner, Kim& Karnsakul, Wikrom. A Challenge for Diagnosing Acute Liver Injury with ConcomitantSequential Exposure to Multiple Drugs: Can Causality Assessment Scales Be Utilized to Identify the Offending Drug?. Case Reports in Pediatrics. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1017544
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1017544