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MicroRNA-21 Promotes Cell Growth and Migration by Targeting Programmed Cell Death 4 Gene in Kazakh’s Esophageal Squamous Cell Carcinoma
المؤلفون المشاركون
Liu, Tao
Liu, Qing
Zheng, Shutao
Gao, Xiangpeng
Lu, Mang
Yang, Chenchen
Dai, Fang
Sheyhidin, Ilyar
Lu, Xiaomei
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-10-21
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Esophageal cancer (EC) is the eighth most common cancer worldwide and the sixth most common cause of cancer death.
There are two main types of EC—squamous cell carcinoma (ESCC) and adenocarcinoma (EAC).
Although some advances in the exploration of its possible etiological mechanism were made recently including behaviors and environmental risk factors as well as gene alterations, the molecular mechanism underlying ESCC carcinogenesis and progression remains poorly understood.
It has been reported that miR-21 was upregulated in most malignant cancers, the proposed mechanism of which was through suppressing expression of programmed cell death 4 (PDCD4).
In present study, it is firstly reported that miR-21 was upregulated in Kazakh’s ESCC and that miR-21 played a negative role in regulating PDCD4 using in situ hybridization (ISH) and luciferase reporter approach.
Morever, in model of ESCC xenografted nude mice, miR-21 maybe used as an effective target in the treatment.
The present results demonstrated that miR-21 may be a potential therapeutic target in management of ESCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Tao& Liu, Qing& Zheng, Shutao& Gao, Xiangpeng& Lu, Mang& Yang, Chenchen…[et al.]. 2014. MicroRNA-21 Promotes Cell Growth and Migration by Targeting Programmed Cell Death 4 Gene in Kazakh’s Esophageal Squamous Cell Carcinoma. Disease Markers،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1017993
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Tao…[et al.]. MicroRNA-21 Promotes Cell Growth and Migration by Targeting Programmed Cell Death 4 Gene in Kazakh’s Esophageal Squamous Cell Carcinoma. Disease Markers No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1017993
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Tao& Liu, Qing& Zheng, Shutao& Gao, Xiangpeng& Lu, Mang& Yang, Chenchen…[et al.]. MicroRNA-21 Promotes Cell Growth and Migration by Targeting Programmed Cell Death 4 Gene in Kazakh’s Esophageal Squamous Cell Carcinoma. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1017993
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1017993
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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