MicroRNA-21 Promotes Cell Growth and Migration by Targeting Programmed Cell Death 4 Gene in Kazakh’s Esophageal Squamous Cell Carcinoma
Joint Authors
Liu, Tao
Liu, Qing
Zheng, Shutao
Gao, Xiangpeng
Lu, Mang
Yang, Chenchen
Dai, Fang
Sheyhidin, Ilyar
Lu, Xiaomei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Esophageal cancer (EC) is the eighth most common cancer worldwide and the sixth most common cause of cancer death.
There are two main types of EC—squamous cell carcinoma (ESCC) and adenocarcinoma (EAC).
Although some advances in the exploration of its possible etiological mechanism were made recently including behaviors and environmental risk factors as well as gene alterations, the molecular mechanism underlying ESCC carcinogenesis and progression remains poorly understood.
It has been reported that miR-21 was upregulated in most malignant cancers, the proposed mechanism of which was through suppressing expression of programmed cell death 4 (PDCD4).
In present study, it is firstly reported that miR-21 was upregulated in Kazakh’s ESCC and that miR-21 played a negative role in regulating PDCD4 using in situ hybridization (ISH) and luciferase reporter approach.
Morever, in model of ESCC xenografted nude mice, miR-21 maybe used as an effective target in the treatment.
The present results demonstrated that miR-21 may be a potential therapeutic target in management of ESCC.
American Psychological Association (APA)
Liu, Tao& Liu, Qing& Zheng, Shutao& Gao, Xiangpeng& Lu, Mang& Yang, Chenchen…[et al.]. 2014. MicroRNA-21 Promotes Cell Growth and Migration by Targeting Programmed Cell Death 4 Gene in Kazakh’s Esophageal Squamous Cell Carcinoma. Disease Markers،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1017993
Modern Language Association (MLA)
Liu, Tao…[et al.]. MicroRNA-21 Promotes Cell Growth and Migration by Targeting Programmed Cell Death 4 Gene in Kazakh’s Esophageal Squamous Cell Carcinoma. Disease Markers No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1017993
American Medical Association (AMA)
Liu, Tao& Liu, Qing& Zheng, Shutao& Gao, Xiangpeng& Lu, Mang& Yang, Chenchen…[et al.]. MicroRNA-21 Promotes Cell Growth and Migration by Targeting Programmed Cell Death 4 Gene in Kazakh’s Esophageal Squamous Cell Carcinoma. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1017993
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1017993