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Antidiabetic Effect of Methanolic Extract from Berberis julianae Schneid. via Activation of AMP-Activated Protein Kinase in Type 2 Diabetic Mice
المؤلفون المشاركون
Yang, Jing
Zhao, Ping
Wan, Dingrong
Zhou, Qi
Wang, Chao
Shu, Guangwen
Mei, Zhinan
Yang, Xinzhou
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-02
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
We have investigated the antidiabetic effect and mechanism of methanolic extract of Berberis julianae Schneid.
(BJSME) in STZ induced Type 2 diabetes mellitus mice.
T2DM mice were induced by high fat diet and low dose streptozotocin (STZ).
BJSME was orally administrated at the doses of 60, 120, and 240 mg/kg/d, for 21 days.
Metformin was used as positive control drug.
Food intake, body weight, plasma glucose, oral glucose tolerance test, insulin tolerance test, insulin, and blood-lipid content were measured.
The effects of BJSME on the glucose transporter 4 (GLUT4) translocation in L6 myotubes and the GLUT4 protein expression in skeletal muscle as well as phosphorylation of the AMP-activated protein kinase (AMPK) in liver and muscle were examined.
In vitro and in vivo results indicate that BJSME increased GLUT4 translocation by 1.8-fold and BJSME significantly improved the oral glucose tolerance and low density lipoprotein cholesterol (LDL-C) of serum and reduced body weight, glucose, and other related blood-lipid contents.
The BJSME treatment also stimulated the phosphorylation of AMPK.
Thus, BJSME seems to possess promising beneficial effects for the treatment of T2DM with the possible mechanism via stimulating AMPK activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Jing& Zhao, Ping& Wan, Dingrong& Zhou, Qi& Wang, Chao& Shu, Guangwen…[et al.]. 2014. Antidiabetic Effect of Methanolic Extract from Berberis julianae Schneid. via Activation of AMP-Activated Protein Kinase in Type 2 Diabetic Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1018084
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Jing…[et al.]. Antidiabetic Effect of Methanolic Extract from Berberis julianae Schneid. via Activation of AMP-Activated Protein Kinase in Type 2 Diabetic Mice. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1018084
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Jing& Zhao, Ping& Wan, Dingrong& Zhou, Qi& Wang, Chao& Shu, Guangwen…[et al.]. Antidiabetic Effect of Methanolic Extract from Berberis julianae Schneid. via Activation of AMP-Activated Protein Kinase in Type 2 Diabetic Mice. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1018084
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1018084
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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