Antidiabetic Effect of Methanolic Extract from Berberis julianae Schneid. via Activation of AMP-Activated Protein Kinase in Type 2 Diabetic Mice
Joint Authors
Yang, Jing
Zhao, Ping
Wan, Dingrong
Zhou, Qi
Wang, Chao
Shu, Guangwen
Mei, Zhinan
Yang, Xinzhou
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
We have investigated the antidiabetic effect and mechanism of methanolic extract of Berberis julianae Schneid.
(BJSME) in STZ induced Type 2 diabetes mellitus mice.
T2DM mice were induced by high fat diet and low dose streptozotocin (STZ).
BJSME was orally administrated at the doses of 60, 120, and 240 mg/kg/d, for 21 days.
Metformin was used as positive control drug.
Food intake, body weight, plasma glucose, oral glucose tolerance test, insulin tolerance test, insulin, and blood-lipid content were measured.
The effects of BJSME on the glucose transporter 4 (GLUT4) translocation in L6 myotubes and the GLUT4 protein expression in skeletal muscle as well as phosphorylation of the AMP-activated protein kinase (AMPK) in liver and muscle were examined.
In vitro and in vivo results indicate that BJSME increased GLUT4 translocation by 1.8-fold and BJSME significantly improved the oral glucose tolerance and low density lipoprotein cholesterol (LDL-C) of serum and reduced body weight, glucose, and other related blood-lipid contents.
The BJSME treatment also stimulated the phosphorylation of AMPK.
Thus, BJSME seems to possess promising beneficial effects for the treatment of T2DM with the possible mechanism via stimulating AMPK activity.
American Psychological Association (APA)
Yang, Jing& Zhao, Ping& Wan, Dingrong& Zhou, Qi& Wang, Chao& Shu, Guangwen…[et al.]. 2014. Antidiabetic Effect of Methanolic Extract from Berberis julianae Schneid. via Activation of AMP-Activated Protein Kinase in Type 2 Diabetic Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1018084
Modern Language Association (MLA)
Yang, Jing…[et al.]. Antidiabetic Effect of Methanolic Extract from Berberis julianae Schneid. via Activation of AMP-Activated Protein Kinase in Type 2 Diabetic Mice. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1018084
American Medical Association (AMA)
Yang, Jing& Zhao, Ping& Wan, Dingrong& Zhou, Qi& Wang, Chao& Shu, Guangwen…[et al.]. Antidiabetic Effect of Methanolic Extract from Berberis julianae Schneid. via Activation of AMP-Activated Protein Kinase in Type 2 Diabetic Mice. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1018084
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018084