Protection Effect of Zhen-Wu-Tang on Adriamycin-Induced Nephrotic Syndrome via Inhibiting Oxidative Lesions and Inflammation Damage
المؤلفون المشاركون
Liang, Chun-ling
Wu, Jun-biao
Lai, Jie-mei
Ye, Shu-fang
Lin, Jin
Ouyang, Hui
Zhan, Janis Ya-xian
Zhou, Jiu-yao
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-09
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Zhen-wu-tang (ZWT), a well-known formula in China, is widely used to treat chronic kidney diseases.
However, very little information on ZWT’s mechanism of action is currently available.
In this study, we investigated the possible protective role and underlying mechanism of ZWT on nephrotic syndrome (NS) induced by Adriamycin (intravenous injection, 6.0 mg/kg) in rats using biochemical and histopathological approaches.
ZWT decreased urine protein excretion and the serum levels of total cholesterol, triglycerides, blood urea nitrogen, and creatinine significantly in diseased rats.
A decrease in plasma levels of total protein and albumin was also recorded in nephropathic rats.
Pathological results show an improved pathological state and recovering glomerular structure in ZWT treatment groups.
ZWT decreased renal IL-8 level but increased renal IL-4 level.
In addition, rats subjected to ZWT exhibited less IgG deposition in glomerulus compared with model group.
RT-PCR results showed that ZWT decreased the mRNA expression of NF-κB p65 and increased the mRNA expression of IκB.
Furthermore, ZWT reduced the level of MDA and increased SOD activity.
These results demonstrated that ZWT ameliorated Adriamycin-induced NS in rats possibly by inhibiting Adriamycin-induced inflammation damage, enhancing body’s antioxidant capacity, thereby protecting glomerulus from injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liang, Chun-ling& Wu, Jun-biao& Lai, Jie-mei& Ye, Shu-fang& Lin, Jin& Ouyang, Hui…[et al.]. 2014. Protection Effect of Zhen-Wu-Tang on Adriamycin-Induced Nephrotic Syndrome via Inhibiting Oxidative Lesions and Inflammation Damage. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1018113
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liang, Chun-ling…[et al.]. Protection Effect of Zhen-Wu-Tang on Adriamycin-Induced Nephrotic Syndrome via Inhibiting Oxidative Lesions and Inflammation Damage. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1018113
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liang, Chun-ling& Wu, Jun-biao& Lai, Jie-mei& Ye, Shu-fang& Lin, Jin& Ouyang, Hui…[et al.]. Protection Effect of Zhen-Wu-Tang on Adriamycin-Induced Nephrotic Syndrome via Inhibiting Oxidative Lesions and Inflammation Damage. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1018113
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1018113
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر