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Protection Effect of Zhen-Wu-Tang on Adriamycin-Induced Nephrotic Syndrome via Inhibiting Oxidative Lesions and Inflammation Damage
Joint Authors
Liang, Chun-ling
Wu, Jun-biao
Lai, Jie-mei
Ye, Shu-fang
Lin, Jin
Ouyang, Hui
Zhan, Janis Ya-xian
Zhou, Jiu-yao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Zhen-wu-tang (ZWT), a well-known formula in China, is widely used to treat chronic kidney diseases.
However, very little information on ZWT’s mechanism of action is currently available.
In this study, we investigated the possible protective role and underlying mechanism of ZWT on nephrotic syndrome (NS) induced by Adriamycin (intravenous injection, 6.0 mg/kg) in rats using biochemical and histopathological approaches.
ZWT decreased urine protein excretion and the serum levels of total cholesterol, triglycerides, blood urea nitrogen, and creatinine significantly in diseased rats.
A decrease in plasma levels of total protein and albumin was also recorded in nephropathic rats.
Pathological results show an improved pathological state and recovering glomerular structure in ZWT treatment groups.
ZWT decreased renal IL-8 level but increased renal IL-4 level.
In addition, rats subjected to ZWT exhibited less IgG deposition in glomerulus compared with model group.
RT-PCR results showed that ZWT decreased the mRNA expression of NF-κB p65 and increased the mRNA expression of IκB.
Furthermore, ZWT reduced the level of MDA and increased SOD activity.
These results demonstrated that ZWT ameliorated Adriamycin-induced NS in rats possibly by inhibiting Adriamycin-induced inflammation damage, enhancing body’s antioxidant capacity, thereby protecting glomerulus from injury.
American Psychological Association (APA)
Liang, Chun-ling& Wu, Jun-biao& Lai, Jie-mei& Ye, Shu-fang& Lin, Jin& Ouyang, Hui…[et al.]. 2014. Protection Effect of Zhen-Wu-Tang on Adriamycin-Induced Nephrotic Syndrome via Inhibiting Oxidative Lesions and Inflammation Damage. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1018113
Modern Language Association (MLA)
Liang, Chun-ling…[et al.]. Protection Effect of Zhen-Wu-Tang on Adriamycin-Induced Nephrotic Syndrome via Inhibiting Oxidative Lesions and Inflammation Damage. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1018113
American Medical Association (AMA)
Liang, Chun-ling& Wu, Jun-biao& Lai, Jie-mei& Ye, Shu-fang& Lin, Jin& Ouyang, Hui…[et al.]. Protection Effect of Zhen-Wu-Tang on Adriamycin-Induced Nephrotic Syndrome via Inhibiting Oxidative Lesions and Inflammation Damage. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1018113
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018113